Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-10

AUTHORS

ROLF M. ZINKEAGEL, PETER C. DOHERTY

ABSTRACT

THE cytotoxic activity1,2 of immune thymus-derived lymphocytes (T cells) for 51Cr-labelled fibroblasts, or macrophages infected with lymphocytic choriomeningitis (LCM) virus is restricted by the H-2 gene complex3,4. Specific lysis of LCM-infected monolayer cultures occurs only when targets and overlaying, sensitised T cells share at least one set of H-2 antigenic specificities. More... »

PAGES

547-548

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/251547a0

DOI

http://dx.doi.org/10.1038/251547a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013519329

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4547543


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