Marrow environment not required for differentiation of B lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-10

AUTHORS

R. A. PHILLIPS, R. G. MILLER

ABSTRACT

IN birds, B lymphocytes differentiate from primitive progenitors in the Bursa of Fabricius, which is thought to provide a unique inductive stimulus, as the thymus in both birds and mammals is thought to provide a stimulus for the differentiation of T lymphocytes. A bursal equivalent has not, however, been identified in mammals. Two proposed sites are the bone marrow1 and the gut-associated lymphoid tissue2. We now have evidence, however, that the bone marrow is not an essential site for the differentiation of B lymphocytes in mammals. More... »

PAGES

444-446

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/251444a0

DOI

http://dx.doi.org/10.1038/251444a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038724365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4608884


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