Differential staining of human and mouse chromosomes in interspecific cell hybrids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-09

AUTHORS

MIN BOBROW, JANE CROSS

ABSTRACT

VIRUS-MEDIATED fusion of somatic cells to produce interspecific cell hybrids has proved to be a most valuable technique for biological research1. Such crosses often undergo an initial fairly random loss of many chromosomes of one parent before karyotypic stability is reached. This property can be used to generate clones of cells each containing a small selection of human chromosomes in a background genotype of some other species. Comparisons of such cell lines provide a form of segregation analysis which can substitute for more traditional genetic methods, particularly in studies on man where classical genetic methodology is difficult to apply. More... »

PAGES

77

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/251077a0

DOI

http://dx.doi.org/10.1038/251077a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010269144

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4137611


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