Activation of guanyl cyclase and intracellular cyclic GMP by fibroblast growth factor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-08

AUTHORS

P. S. RUDLAND, D. GOSPODAROWICZ, W. SEIFERT

ABSTRACT

THE induction of cell growth by animal serum in quiescent cultured fibroblasts is preceded by a sequence of regulated steps1. These steps include stimulation of cellular transport systems1, protein synthesis1, ribosomal and tRNA synthesis2 and eventually the induction of DNA synthesis followed by cell division3,4. Two of the earliest changes observed after growth induction by serum are a transient increase in intracellular cyclic GMP5 (10-fold) and a decrease in cyclic AMP (two-to-threefold)5,6,7. It has been suggested that cyclic GMP acts as a positive intracellular signal for cell growth since intracellular cyclic GMP concentrations showed an early transient increase upon growth induction by phytohaemagglutinin whereas no changes were observed in cyclic AMP concentrations8, and additions of high, non-physiological (10−6 to 10−4 M) concentrations of cyclic GMP can induce substantial increases in DNA synthesis in resting fibroblasts5. Recently a new polypeptide hormone, fibroblast growth factor (FGF), was isolated from bovine pituitary glands9. FGF in combination with the glucocorticoid, hydrocortisone, and a nonspecific carrier protein, bovine serum albumin (BSA), can completely replace exogenously added serum in bringing about all the steps leading to the initiation of DNA synthesis and cell division in some lines of BALB/c 3T3 cells10. Hydrocortisone, as it fails to initiate DNA synthesis alone in the absence of serum11 is considered to potentiate the action of FGF9 (permissive effect). More... »

PAGES

741

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/250741a0

DOI

http://dx.doi.org/10.1038/250741a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040806115

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4153265


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