Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-05

AUTHORS

KEVIN J. LAFFERTY, IHOR S. MISKO, MARGARET A. COOLEY

ABSTRACT

THE theory of allogeneic stimulation1 postulates that transplantation antigens, such as H-2 in the mouse or H-LA in man, are not strong immunogens for allogeneic animals, but are rendered highly immunogenic when presented to the immune system in conjunction with an allogeneic stimulus. The capacity to provide an allogeneic stimulus is the property of metabolically active2–4 immunocompetent cells1, and it has been suggested that allogeneic stimulation requires the transfer of some cytoplasmic component from the stimulating to the responsive cell1. According to this hypothesis, any treatment that inactivates the metabolic activity of lymphoid cells will reduce their immunogenicity for other members of the same species. More... »

PAGES

275-276

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/249275a0

DOI

http://dx.doi.org/10.1038/249275a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011863782

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4275319


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody-Producing Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxicity Tests, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immune Sera", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Culture Test, Mixed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred CBA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Effects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spleen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tritium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultraviolet Rays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1001.0", 
          "name": [
            "Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LAFFERTY", 
        "givenName": "KEVIN J.", 
        "id": "sg:person.01321547644.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321547644.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1001.0", 
          "name": [
            "Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MISKO", 
        "givenName": "IHOR S.", 
        "id": "sg:person.01074254430.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074254430.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1001.0", 
          "name": [
            "Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "COOLEY", 
        "givenName": "MARGARET A.", 
        "id": "sg:person.0107465625.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107465625.67"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1974-05", 
    "datePublishedReg": "1974-05-01", 
    "description": "THE theory of allogeneic stimulation1 postulates that transplantation antigens, such as H-2 in the mouse or H-LA in man, are not strong immunogens for allogeneic animals, but are rendered highly immunogenic when presented to the immune system in conjunction with an allogeneic stimulus. The capacity to provide an allogeneic stimulus is the property of metabolically active2\u20134 immunocompetent cells1, and it has been suggested that allogeneic stimulation requires the transfer of some cytoplasmic component from the stimulating to the responsive cell1. According to this hypothesis, any treatment that inactivates the metabolic activity of lymphoid cells will reduce their immunogenicity for other members of the same species.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/249275a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5454", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "249"
      }
    ], 
    "keywords": [
      "allogeneic stimulation", 
      "allogeneic stimuli", 
      "allogeneic animals", 
      "lymphoid cells", 
      "transplantation antigens", 
      "strong immunogen", 
      "immune system", 
      "antigen", 
      "stimulation", 
      "metabolic activity", 
      "cells", 
      "stimuli", 
      "immunogenicity", 
      "mice", 
      "immunogen", 
      "men", 
      "treatment", 
      "Cells1", 
      "stimulating", 
      "cytoplasmic components", 
      "animals", 
      "response", 
      "activity", 
      "hypothesis", 
      "members", 
      "conjunction", 
      "cell1", 
      "capacity", 
      "same species", 
      "components", 
      "La", 
      "system", 
      "transfer", 
      "species", 
      "properties", 
      "theory"
    ], 
    "name": "Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen", 
    "pagination": "275-276", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011863782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/249275a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4275319"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/249275a0", 
      "https://app.dimensions.ai/details/publication/pub.1011863782"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T21:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_119.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/249275a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/249275a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/249275a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/249275a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/249275a0'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      20 PREDICATES      83 URIs      75 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/249275a0 schema:about N054ac703c6b6489299db759ef304cbd9
2 N0737d8d3a16a4ba4a69fec662902f350
3 N0ce6edfbc682474fb3f31e8c09387e4a
4 N13cd83e8d91f40a5826113f205962dc8
5 N2a4c40c72ea448dbbe59c9c5fe8861cb
6 N4669d73a352846538293cf7da2d90651
7 N5574a4e45c464296a5c3c42d1be9cc7c
8 N572f6ce4fccd47a3b45f83a7a18c1720
9 N6148d4b375f64e4598daa47a2c893efc
10 N6c57560aca8040c593834ac59542d11f
11 N84e1d34b1278471da4c7f12a9bc182f7
12 N95adb4970e284354937f514a1af789bd
13 N9c05616860ea4ee3a27b04c391e5af06
14 Na60d8b98b43f4887bebb100e122398cb
15 Na70d9a4037724a04807e3566e6b9e89e
16 Nb2bad4f7de8e4d938ba7b0c711bb48de
17 Nbc41cd299afc40379b9e714ae1ecdddf
18 Nc213158d7558435e93ea6f58ab6c728b
19 Nc579f4d1f63f4bef9d19dbb9484fa4cb
20 Ndbe87807f18140b5bdb4bea83ab94c91
21 Nee21ed44c42b48f0ad746535ac733e41
22 anzsrc-for:11
23 anzsrc-for:1107
24 schema:author Na91a1581f24647b5a6e2fd2217057993
25 schema:datePublished 1974-05
26 schema:datePublishedReg 1974-05-01
27 schema:description THE theory of allogeneic stimulation1 postulates that transplantation antigens, such as H-2 in the mouse or H-LA in man, are not strong immunogens for allogeneic animals, but are rendered highly immunogenic when presented to the immune system in conjunction with an allogeneic stimulus. The capacity to provide an allogeneic stimulus is the property of metabolically active2–4 immunocompetent cells1, and it has been suggested that allogeneic stimulation requires the transfer of some cytoplasmic component from the stimulating to the responsive cell1. According to this hypothesis, any treatment that inactivates the metabolic activity of lymphoid cells will reduce their immunogenicity for other members of the same species.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N0a2c4f882a4243ba93a9e692e45ad68a
31 Na48df295bba7488a93d2c84807962acb
32 sg:journal.1018957
33 schema:keywords Cells1
34 La
35 activity
36 allogeneic animals
37 allogeneic stimulation
38 allogeneic stimuli
39 animals
40 antigen
41 capacity
42 cell1
43 cells
44 components
45 conjunction
46 cytoplasmic components
47 hypothesis
48 immune system
49 immunogen
50 immunogenicity
51 lymphoid cells
52 members
53 men
54 metabolic activity
55 mice
56 properties
57 response
58 same species
59 species
60 stimulating
61 stimulation
62 stimuli
63 strong immunogen
64 system
65 theory
66 transfer
67 transplantation antigens
68 treatment
69 schema:name Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen
70 schema:pagination 275-276
71 schema:productId N2076871fa7d44d9a9a77321e08f8158a
72 N86362ec7f9064e3e9e8901587c1bbe84
73 N99a85d4e1232438cb8678f6988b9cb29
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011863782
75 https://doi.org/10.1038/249275a0
76 schema:sdDatePublished 2022-06-01T21:57
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nce5acef86b474793a92084787847c077
79 schema:url https://doi.org/10.1038/249275a0
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N054ac703c6b6489299db759ef304cbd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Lymphocyte Culture Test, Mixed
85 rdf:type schema:DefinedTerm
86 N0737d8d3a16a4ba4a69fec662902f350 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Lymph Nodes
88 rdf:type schema:DefinedTerm
89 N0a2c4f882a4243ba93a9e692e45ad68a schema:volumeNumber 249
90 rdf:type schema:PublicationVolume
91 N0ce6edfbc682474fb3f31e8c09387e4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name In Vitro Techniques
93 rdf:type schema:DefinedTerm
94 N13cd83e8d91f40a5826113f205962dc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Radiation Effects
96 rdf:type schema:DefinedTerm
97 N2076871fa7d44d9a9a77321e08f8158a schema:name doi
98 schema:value 10.1038/249275a0
99 rdf:type schema:PropertyValue
100 N2a4c40c72ea448dbbe59c9c5fe8861cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Animals
102 rdf:type schema:DefinedTerm
103 N4669d73a352846538293cf7da2d90651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice, Inbred BALB C
105 rdf:type schema:DefinedTerm
106 N5574a4e45c464296a5c3c42d1be9cc7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Transplantation Immunology
108 rdf:type schema:DefinedTerm
109 N572f6ce4fccd47a3b45f83a7a18c1720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lymphocytes
111 rdf:type schema:DefinedTerm
112 N6148d4b375f64e4598daa47a2c893efc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Thymidine
114 rdf:type schema:DefinedTerm
115 N6c57560aca8040c593834ac59542d11f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Lymphocyte Activation
117 rdf:type schema:DefinedTerm
118 N83303c31e5854e588ce7df893d9d3479 rdf:first sg:person.01074254430.10
119 rdf:rest N928801b8f471412596c640d310425d66
120 N84e1d34b1278471da4c7f12a9bc182f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mice
122 rdf:type schema:DefinedTerm
123 N86362ec7f9064e3e9e8901587c1bbe84 schema:name dimensions_id
124 schema:value pub.1011863782
125 rdf:type schema:PropertyValue
126 N928801b8f471412596c640d310425d66 rdf:first sg:person.0107465625.67
127 rdf:rest rdf:nil
128 N95adb4970e284354937f514a1af789bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name T-Lymphocytes
130 rdf:type schema:DefinedTerm
131 N99a85d4e1232438cb8678f6988b9cb29 schema:name pubmed_id
132 schema:value 4275319
133 rdf:type schema:PropertyValue
134 N9c05616860ea4ee3a27b04c391e5af06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mice, Inbred C57BL
136 rdf:type schema:DefinedTerm
137 Na48df295bba7488a93d2c84807962acb schema:issueNumber 5454
138 rdf:type schema:PublicationIssue
139 Na60d8b98b43f4887bebb100e122398cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice, Inbred CBA
141 rdf:type schema:DefinedTerm
142 Na70d9a4037724a04807e3566e6b9e89e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Cytotoxicity Tests, Immunologic
144 rdf:type schema:DefinedTerm
145 Na91a1581f24647b5a6e2fd2217057993 rdf:first sg:person.01321547644.98
146 rdf:rest N83303c31e5854e588ce7df893d9d3479
147 Nb2bad4f7de8e4d938ba7b0c711bb48de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Histocompatibility Antigens
149 rdf:type schema:DefinedTerm
150 Nbc41cd299afc40379b9e714ae1ecdddf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Spleen
152 rdf:type schema:DefinedTerm
153 Nc213158d7558435e93ea6f58ab6c728b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Antibody-Producing Cells
155 rdf:type schema:DefinedTerm
156 Nc579f4d1f63f4bef9d19dbb9484fa4cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Immune Sera
158 rdf:type schema:DefinedTerm
159 Nce5acef86b474793a92084787847c077 schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Ndbe87807f18140b5bdb4bea83ab94c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Ultraviolet Rays
163 rdf:type schema:DefinedTerm
164 Nee21ed44c42b48f0ad746535ac733e41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Tritium
166 rdf:type schema:DefinedTerm
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
171 schema:name Immunology
172 rdf:type schema:DefinedTerm
173 sg:journal.1018957 schema:issn 0028-0836
174 1476-4687
175 schema:name Nature
176 schema:publisher Springer Nature
177 rdf:type schema:Periodical
178 sg:person.01074254430.10 schema:affiliation grid-institutes:grid.1001.0
179 schema:familyName MISKO
180 schema:givenName IHOR S.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074254430.10
182 rdf:type schema:Person
183 sg:person.0107465625.67 schema:affiliation grid-institutes:grid.1001.0
184 schema:familyName COOLEY
185 schema:givenName MARGARET A.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107465625.67
187 rdf:type schema:Person
188 sg:person.01321547644.98 schema:affiliation grid-institutes:grid.1001.0
189 schema:familyName LAFFERTY
190 schema:givenName KEVIN J.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321547644.98
192 rdf:type schema:Person
193 grid-institutes:grid.1001.0 schema:alternateName Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia
194 schema:name Department of Immunology, John Curtin School of Medical Research, The Australian National University, P.O. Box 334, 2601, Canberra City, ACT, Australia
195 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...