Ontology type: schema:ScholarlyArticle
1974-05
AUTHORS ABSTRACTBACTERIAL lipopolysaccharides (LPS) stimulate DNA synthesis specifically in B (thymus-independent) lymphocytes1–4, increase immunoglobulin synthesis and secretion in B cells5, and stimulate the immune response of antibody production to various antigens in the apparent absence of T (thymus-dependent) lymphocytes4,6–8. Recently a mouse B lymphosarcoma, PU-5-1, has been described which has surface immunoglobulin9, and produces a small amount of immunoglobulin (R. Asofsky, unpublished). Cells of this tumour were adapted to culture and tested for the LPS stimulation of immunoglobulin secretion. Surprisingly, growth of the tumour cells was inhibited by LPS, although there was no effect on mouse myelomas or T lymphomas. Inhibition also occurred with an Abelson leukaemia virus induced tumour believed to represent a B lymphoma10 or immature myelomonocytic neoplasm11. No effect was observed on the growth rate of a number of human B cell lines tested. LPS is not cytotoxic for the tumour cells: growth resumes when it is removed. Incorporation of precursors into DNA is inhibited before RNA and protein synthesis is affected. The active component of LPS seems to be the lipid A, as shown for its pyrogenic12, mitogenic8,13–15, and adjuvant8,13 properties. More... »
PAGES49
http://scigraph.springernature.com/pub.10.1038/249049a0
DOIhttp://dx.doi.org/10.1038/249049a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017817111
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/4208429
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Division",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Erythroblastic, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Myeloid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lipopolysaccharides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphoma, Non-Hodgkin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mast-Cell Sarcoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Multiple Myeloma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polysaccharides, Bacterial",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Salmonella typhi",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tritium",
"type": "DefinedTerm"
}
],
"author": [
{
"familyName": "RAL",
"givenName": "PETER",
"id": "sg:person.015627243313.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015627243313.95"
],
"type": "Person"
},
{
"familyName": "NAKOINZ",
"givenName": "ILONA",
"id": "sg:person.061370650.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.061370650.22"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/0022-2836(73)90487-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001857269"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.70.7.2129",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006274825"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4615-9017-0_71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011105212",
"https://doi.org/10.1007/978-1-4615-9017-0_71"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.136.2.392",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011245877"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0008-8749(72)90040-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018034806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.138.3.699",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019750270"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio240198a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022876104",
"https://doi.org/10.1038/newbio240198a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio240198a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022876104",
"https://doi.org/10.1038/newbio240198a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio240198a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022876104",
"https://doi.org/10.1038/newbio240198a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1971.tb01298.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032400965"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio245108a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037511940",
"https://doi.org/10.1038/newbio245108a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio245108a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037511940",
"https://doi.org/10.1038/newbio245108a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio245108a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037511940",
"https://doi.org/10.1038/newbio245108a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio245012a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051215431",
"https://doi.org/10.1038/newbio245012a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio245012a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051215431",
"https://doi.org/10.1038/newbio245012a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/newbio245012a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051215431",
"https://doi.org/10.1038/newbio245012a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/infdis/128.supplement_1.s232",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059695133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.182.4112.592",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062508479"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080141329",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080175134",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080272874",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080289826",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080428172",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/51.3.883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1080429085"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080437151",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080452252",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080686700",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080701158",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080757525",
"type": "CreativeWork"
}
],
"datePublished": "1974-05",
"datePublishedReg": "1974-05-01",
"description": "BACTERIAL lipopolysaccharides (LPS) stimulate DNA synthesis specifically in B (thymus-independent) lymphocytes1\u20134, increase immunoglobulin synthesis and secretion in B cells5, and stimulate the immune response of antibody production to various antigens in the apparent absence of T (thymus-dependent) lymphocytes4,6\u20138. Recently a mouse B lymphosarcoma, PU-5-1, has been described which has surface immunoglobulin9, and produces a small amount of immunoglobulin (R. Asofsky, unpublished). Cells of this tumour were adapted to culture and tested for the LPS stimulation of immunoglobulin secretion. Surprisingly, growth of the tumour cells was inhibited by LPS, although there was no effect on mouse myelomas or T lymphomas. Inhibition also occurred with an Abelson leukaemia virus induced tumour believed to represent a B lymphoma10 or immature myelomonocytic neoplasm11. No effect was observed on the growth rate of a number of human B cell lines tested. LPS is not cytotoxic for the tumour cells: growth resumes when it is removed. Incorporation of precursors into DNA is inhibited before RNA and protein synthesis is affected. The active component of LPS seems to be the lipid A, as shown for its pyrogenic12, mitogenic8,13\u201315, and adjuvant8,13 properties.",
"genre": "research_article",
"id": "sg:pub.10.1038/249049a0",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "5452",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "249"
}
],
"name": "Lipopolysaccharides inhibit lymphosarcoma cells of bone marrow origin",
"pagination": "49",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"54e4a20d536b9adc8654ca8b48d958028086cca1334cd2307ddb6e7bd2cabf0a"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"4208429"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/249049a0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017817111"
]
}
],
"sameAs": [
"https://doi.org/10.1038/249049a0",
"https://app.dimensions.ai/details/publication/pub.1017817111"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:46",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/249049a0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/249049a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/249049a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/249049a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/249049a0'
This table displays all metadata directly associated to this object as RDF triples.
218 TRIPLES
21 PREDICATES
73 URIs
42 LITERALS
30 BLANK NODES