Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-04

AUTHORS

GENKI KIMURA

ABSTRACT

HUMAN adenoviruses undergo a complete cycle of replication in human cells, but cause an abortive infection in simian cells. In the simian cells infected with the human adenovirus, early adenovirus-specific T antigen is induced1,2, viral DNA is replicated to the same level as in productive cycles of replication3,4, and no change in the synthesis of viral mRNA can be detected5,6. However, only limited amounts of viral capsid proteins are made in relatively few cells1,2,6–8. If the simian cells are coinfected with simian virus 40 (SV40), the nonproductive cycle of replication of human adenoviruses is changed to a productive cycle9,10. This helper effect of infection by SV40 is thought to be under the control of SV40 gene function, but there has been no direct evidence for this. Using temperature-sensitive (ts) mutants of SV40, I have now found such evidence. More... »

PAGES

590-592

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/248590a0

DOI

http://dx.doi.org/10.1038/248590a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044864145

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4363086


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Defective Viruses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Code", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplorhini", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helper Viruses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simian virus 40", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temperature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Plaque Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Bacteriology, Tottori University School of Medicine, 683, Yonago", 
          "id": "http://www.grid.ac/institutes/grid.265107.7", 
          "name": [
            "Department of Bacteriology, Tottori University School of Medicine, 683, Yonago"
          ], 
          "type": "Organization"
        }, 
        "familyName": "KIMURA", 
        "givenName": "GENKI", 
        "id": "sg:person.07531743012.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531743012.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/newbio233039a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003788448", 
          "https://doi.org/10.1038/newbio233039a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1974-04", 
    "datePublishedReg": "1974-04-01", 
    "description": "HUMAN adenoviruses undergo a complete cycle of replication in human cells, but cause an abortive infection in simian cells. In the simian cells infected with the human adenovirus, early adenovirus-specific T antigen is induced1,2, viral DNA is replicated to the same level as in productive cycles of replication3,4, and no change in the synthesis of viral mRNA can be detected5,6. However, only limited amounts of viral capsid proteins are made in relatively few cells1,2,6\u20138. If the simian cells are coinfected with simian virus 40 (SV40), the nonproductive cycle of replication of human adenoviruses is changed to a productive cycle9,10. This helper effect of infection by SV40 is thought to be under the control of SV40 gene function, but there has been no direct evidence for this. Using temperature-sensitive (ts) mutants of SV40, I have now found such evidence.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/248590a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5449", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "248"
      }
    ], 
    "keywords": [
      "human adenoviruses", 
      "simian cells", 
      "enhancement of replication", 
      "helper effect", 
      "abortive infection", 
      "adenovirus", 
      "viral capsid proteins", 
      "infection", 
      "viral DNA", 
      "simian virus 40", 
      "T antigen", 
      "cells", 
      "viral mRNAs", 
      "capsid protein", 
      "human cells", 
      "evidence", 
      "antigen", 
      "replication", 
      "SV40", 
      "direct evidence", 
      "such evidence", 
      "genetic evidence", 
      "same level", 
      "productive cycle", 
      "mRNA", 
      "function", 
      "levels", 
      "control", 
      "protein", 
      "temperature-sensitive mutant", 
      "gene function", 
      "effect", 
      "cycle", 
      "changes", 
      "DNA", 
      "limited amount", 
      "complete cycle", 
      "mutants", 
      "amount", 
      "enhancement", 
      "synthesis"
    ], 
    "name": "Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells", 
    "pagination": "590-592", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044864145"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/248590a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4363086"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/248590a0", 
      "https://app.dimensions.ai/details/publication/pub.1044864145"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_137.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/248590a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/248590a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/248590a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/248590a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/248590a0'


 

This table displays all metadata directly associated to this object as RDF triples.

166 TRIPLES      21 PREDICATES      83 URIs      74 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/248590a0 schema:about N0724e858e3084c068c8d6162c314f919
2 N13de8e3043514351bb6769df871086b8
3 N1aed73fb4de14b708874cdb7e31dff82
4 N39adf09ede304d84acf4e0bbb5444c26
5 N543984a1e074434ba3e81432f023d84c
6 N5d8973043e4b436b978161a8c245e17c
7 N6179431beef04506a7ddb4119f8184df
8 N7509539fa5ba43158c023b7f1d44aff0
9 N79ab2030f0ec4927ba7a7a38edadc726
10 N82f083e27eeb44eea19b95cc6231b9d7
11 N83527620cbd74bf7bd43218d31c245ed
12 N8721fb8ab0a84f85803278470f452d4a
13 Nc18930aed70847b6ae6666f6bbb097e9
14 Nccc51e5852d34a85b2de4e74d31cc5dd
15 Ne5d7a87c7044402884a4d039efee43ba
16 anzsrc-for:11
17 anzsrc-for:1108
18 schema:author Necf7ba5e1ebc4e6d90cb1ec75ea4c198
19 schema:citation sg:pub.10.1038/newbio233039a0
20 schema:datePublished 1974-04
21 schema:datePublishedReg 1974-04-01
22 schema:description HUMAN adenoviruses undergo a complete cycle of replication in human cells, but cause an abortive infection in simian cells. In the simian cells infected with the human adenovirus, early adenovirus-specific T antigen is induced1,2, viral DNA is replicated to the same level as in productive cycles of replication3,4, and no change in the synthesis of viral mRNA can be detected5,6. However, only limited amounts of viral capsid proteins are made in relatively few cells1,2,6–8. If the simian cells are coinfected with simian virus 40 (SV40), the nonproductive cycle of replication of human adenoviruses is changed to a productive cycle9,10. This helper effect of infection by SV40 is thought to be under the control of SV40 gene function, but there has been no direct evidence for this. Using temperature-sensitive (ts) mutants of SV40, I have now found such evidence.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N56e3cc04b1f6463b8bce5aa30c111496
26 N6edcfcdc1e954531b0511060666a79ca
27 sg:journal.1018957
28 schema:keywords DNA
29 SV40
30 T antigen
31 abortive infection
32 adenovirus
33 amount
34 antigen
35 capsid protein
36 cells
37 changes
38 complete cycle
39 control
40 cycle
41 direct evidence
42 effect
43 enhancement
44 enhancement of replication
45 evidence
46 function
47 gene function
48 genetic evidence
49 helper effect
50 human adenoviruses
51 human cells
52 infection
53 levels
54 limited amount
55 mRNA
56 mutants
57 productive cycle
58 protein
59 replication
60 same level
61 simian cells
62 simian virus 40
63 such evidence
64 synthesis
65 temperature-sensitive mutant
66 viral DNA
67 viral capsid proteins
68 viral mRNAs
69 schema:name Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells
70 schema:pagination 590-592
71 schema:productId N0b71af642ea845d29afabe643b8c398e
72 N414a7a6974df411aa035932c05d0c2ab
73 N9e87a62b1d7b4059a32f8513e12a8e1d
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044864145
75 https://doi.org/10.1038/248590a0
76 schema:sdDatePublished 2022-12-01T06:18
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N0952b7bb33364509b539cd1fe49f538d
79 schema:url https://doi.org/10.1038/248590a0
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0724e858e3084c068c8d6162c314f919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Defective Viruses
85 rdf:type schema:DefinedTerm
86 N0952b7bb33364509b539cd1fe49f538d schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N0b71af642ea845d29afabe643b8c398e schema:name dimensions_id
89 schema:value pub.1044864145
90 rdf:type schema:PropertyValue
91 N13de8e3043514351bb6769df871086b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Adenoviridae
93 rdf:type schema:DefinedTerm
94 N1aed73fb4de14b708874cdb7e31dff82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Humans
96 rdf:type schema:DefinedTerm
97 N39adf09ede304d84acf4e0bbb5444c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Kidney
99 rdf:type schema:DefinedTerm
100 N414a7a6974df411aa035932c05d0c2ab schema:name pubmed_id
101 schema:value 4363086
102 rdf:type schema:PropertyValue
103 N543984a1e074434ba3e81432f023d84c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Helper Viruses
105 rdf:type schema:DefinedTerm
106 N56e3cc04b1f6463b8bce5aa30c111496 schema:volumeNumber 248
107 rdf:type schema:PublicationVolume
108 N5d8973043e4b436b978161a8c245e17c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Genetic Code
110 rdf:type schema:DefinedTerm
111 N6179431beef04506a7ddb4119f8184df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N6edcfcdc1e954531b0511060666a79ca schema:issueNumber 5449
115 rdf:type schema:PublicationIssue
116 N7509539fa5ba43158c023b7f1d44aff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Virus Replication
118 rdf:type schema:DefinedTerm
119 N79ab2030f0ec4927ba7a7a38edadc726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mutation
121 rdf:type schema:DefinedTerm
122 N82f083e27eeb44eea19b95cc6231b9d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Viral Plaque Assay
124 rdf:type schema:DefinedTerm
125 N83527620cbd74bf7bd43218d31c245ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Simian virus 40
127 rdf:type schema:DefinedTerm
128 N8721fb8ab0a84f85803278470f452d4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Line
130 rdf:type schema:DefinedTerm
131 N9e87a62b1d7b4059a32f8513e12a8e1d schema:name doi
132 schema:value 10.1038/248590a0
133 rdf:type schema:PropertyValue
134 Nc18930aed70847b6ae6666f6bbb097e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Genes
136 rdf:type schema:DefinedTerm
137 Nccc51e5852d34a85b2de4e74d31cc5dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Haplorhini
139 rdf:type schema:DefinedTerm
140 Ne5d7a87c7044402884a4d039efee43ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Temperature
142 rdf:type schema:DefinedTerm
143 Necf7ba5e1ebc4e6d90cb1ec75ea4c198 rdf:first sg:person.07531743012.70
144 rdf:rest rdf:nil
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
149 schema:name Medical Microbiology
150 rdf:type schema:DefinedTerm
151 sg:journal.1018957 schema:issn 0028-0836
152 1476-4687
153 schema:name Nature
154 schema:publisher Springer Nature
155 rdf:type schema:Periodical
156 sg:person.07531743012.70 schema:affiliation grid-institutes:grid.265107.7
157 schema:familyName KIMURA
158 schema:givenName GENKI
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531743012.70
160 rdf:type schema:Person
161 sg:pub.10.1038/newbio233039a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003788448
162 https://doi.org/10.1038/newbio233039a0
163 rdf:type schema:CreativeWork
164 grid-institutes:grid.265107.7 schema:alternateName Department of Bacteriology, Tottori University School of Medicine, 683, Yonago
165 schema:name Department of Bacteriology, Tottori University School of Medicine, 683, Yonago
166 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...