Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-03

AUTHORS

DAVID BALTIMORE

ABSTRACT

AN enzyme able to add deoxyribonucleotides to the ends of DNA primers has been identified in calf thymus by Bollum and his colleagues and named terminal deoxynucleotidyl transferase1–4. Chang5 has indicated that the enzyme is a specialised constituent of thymus cells and is not present in any other organ of several animal species. The enzyme is located in the lymphocyte fraction of the thymus (Silverstone, Parkman, McCaffrey and Baltimore, unpublished results). Recently, we found an enzyme with the properties of a terminal transferase in circulating lymphoblasts of patients with acute lymphoblastic leukaemia (ref. 6 and McCaffrey, Harrison, and Baltimore, unpublished results). More... »

PAGES

409-411

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/248409a0

DOI

http://dx.doi.org/10.1038/248409a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018708711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4545077


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