Ontology type: schema:ScholarlyArticle
1998-12
AUTHORSMartine Migaud, Paul Charlesworth, Maureen Dempster, Lorna C. Webster, Ayako M. Watabe, Michael Makhinson, Yong He, Mark F. Ramsay, Richard G. M. Morris, John H. Morrison, Thomas J. O'Dell, Seth G. N. Grant
ABSTRACTSpecific patterns of neuronal firing induce changes in synaptic strength that may contribute to learning and memory. If the postsynaptic NMDA (N-methyl-D-aspartate) receptors are blocked, long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission and the learning of spatial information are prevented. The NMDA receptor can bind a protein known as postsynaptic density-95 (PSD-95), which may regulate the localization of and/or signalling by the receptor. In mutant mice lacking PSD-95, the frequency function of NMDA-dependent LTP and LTD is shifted to produce strikingly enhanced LTP at different frequencies of synaptic stimulation. In keeping with neural-network models that incorporate bidirectional learning rules, this frequency shift is accompanied by severely impaired spatial learning. Synaptic NMDA-receptor currents, subunit expression, localization and synaptic morphology are all unaffected in the mutant mice. PSD-95 thus appears to be important in coupling the NMDA receptor to pathways that control bidirectional synaptic plasticity and learning. More... »
PAGES433-439
http://scigraph.springernature.com/pub.10.1038/24790
DOIhttp://dx.doi.org/10.1038/24790
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9853749
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{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1047999009"
]
}
],
"sameAs": [
"https://doi.org/10.1038/24790",
"https://app.dimensions.ai/details/publication/pub.1047999009"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:22",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87088_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/24790"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/24790'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/24790'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/24790'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/24790'
This table displays all metadata directly associated to this object as RDF triples.
354 TRIPLES
21 PREDICATES
88 URIs
42 LITERALS
30 BLANK NODES