Active Synthesis of Immunoglobulin Receptors for Antigen by T Lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-01

AUTHORS

GEORGES E. ROELANTS, AINA RYDÉN, LENA-BRITT HÄGG, FRANCIS LOOR

ABSTRACT

WHEN antigen binding cells (ABC) were studied by combined autoradiography and immunofluorescence it was found that antigen binding to both B and T ABC could be inhibited by anti-immunoglobulin (anti-Ig) reagents1. Moreover, receptors for antigen could be redistributed in caps in a similar way for B and T ABC using non-inhibiting doses of anti-Ig reagents1. Since membrane components are known to redistribute independently of each other2–5 it was concluded from the inhibition and capping experiments that the receptor for antigen on T lymphocytes was immunoglobulin. The fact that T ABC are always a small minority of the total T cell population argues against the possibility that their receptors are passively acquired as cytophilic antibody. We present evidence confirming that T cells have receptors for antigen which are immunoglobulins and showing, in addition, that they are actively synthesised by the cells carrying them. More... »

PAGES

106-108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/247106a0

DOI

http://dx.doi.org/10.1038/247106a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029241022

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4128936


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