New pathway to polyketides in plants View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-11

AUTHORS

Stefan Eckermann, Gudrun Schröder, Jürgen Schmidt, Dieter Strack, Ru A. Edrada, Yrjö Helariutta, Paula Elomaa, Mika Kotilainen, Ilkka Kilpeläinen, Peter Proksch, Teemu H. Teeri, Joachim Schröder

ABSTRACT

The repertoire of secondary metabolism (involving the production of compounds not essential for growth) in the plant kingdom is enormous, but the genetic and functional basis for this diversity is hard to analyse as many of the biosynthetic enzymes are unknown. We have now identified a key enzyme in the ornamental plant Gerbera hybrida (Asteraceae) that participates in the biosynthesis of compounds that contribute to insect and pathogen resistance. Plants transformed with an antisense construct of gchs2, a complementary DNA encoding a previously unknown function1,2, completely lack the pyrone derivatives gerberin and parasorboside. The recombinant plant protein catalyses the principal reaction in the biosynthesis of these derivatives: GCHS2 is a polyketide synthase that uses acetyl-CoA and two condensation reactions with malonyl-CoA to form the pyrone backbone of thenatural products. The enzyme also accepts benzoyl-CoA to synthesize the backbone of substances that have become of interest as inhibitors of the HIV-1 protease3,4,5. GCHS2 is related to chalcone synthase (CHS) and its properties define a new class of function in the protein superfamily. It appears that CHS-related enzymes are involved in the biosynthesis of a much larger range of plant products than was previously realized. More... »

PAGES

387

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/24652

DOI

http://dx.doi.org/10.1038/24652

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050845636


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