Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1973-10

AUTHORS

J. C. FOREMAN, J. L. MONGAR, B. D. GOMPERTS

ABSTRACT

Mast cells can be induced to secrete histamine by an ionophore, the action of which depends on the presence of calcium within a specific concentration range. The fact that labelled calcium can be seen to enter sensitized cells during histamine secretion in the presence of antigen suggests that the entry of calcium into the mast cell may be the trigger for the release of histamine. More... »

PAGES

249-251

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/245249a0

DOI

http://dx.doi.org/10.1038/245249a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020298262

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4126372


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzoates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carboxylic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histamine Release", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Exchange", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnesium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mast Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen Consumption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Strontium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University College London, WC1E 6BT, London", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Pharmacology, University College London, WC1E 6BT, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "FOREMAN", 
        "givenName": "J. C.", 
        "id": "sg:person.054312772.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.054312772.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University College London, WC1E 6BT, London", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Pharmacology, University College London, WC1E 6BT, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MONGAR", 
        "givenName": "J. L.", 
        "id": "sg:person.074063426.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074063426.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental Pathology, University College Hospital Medical School, WC1E 6JJ, London", 
          "id": "http://www.grid.ac/institutes/grid.439749.4", 
          "name": [
            "Department of Experimental Pathology, University College Hospital Medical School, WC1E 6JJ, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "GOMPERTS", 
        "givenName": "B. D.", 
        "id": "sg:person.012737166263.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012737166263.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/236350a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040337943", 
          "https://doi.org/10.1038/236350a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1973-10", 
    "datePublishedReg": "1973-10-01", 
    "description": "Mast cells can be induced to secrete histamine by an ionophore, the action of which depends on the presence of calcium within a specific concentration range. The fact that labelled calcium can be seen to enter sensitized cells during histamine secretion in the presence of antigen suggests that the entry of calcium into the mast cell may be the trigger for the release of histamine.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/245249a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5423", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "245"
      }
    ], 
    "keywords": [
      "mast cells", 
      "release of histamine", 
      "entry of calcium", 
      "presence of antigen", 
      "histamine secretion", 
      "calcium ionophore", 
      "sensitized cells", 
      "physiological stimuli", 
      "secretory process", 
      "histamine", 
      "calcium", 
      "presence of calcium", 
      "cells", 
      "ionophore", 
      "antigen", 
      "secretion", 
      "calcium ions", 
      "presence", 
      "stimuli", 
      "specific concentration range", 
      "release", 
      "triggers", 
      "action", 
      "entry", 
      "concentration range", 
      "movement", 
      "fact", 
      "range", 
      "process", 
      "ions"
    ], 
    "name": "Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process", 
    "pagination": "249-251", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020298262"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/245249a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4126372"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/245249a0", 
      "https://app.dimensions.ai/details/publication/pub.1020298262"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_124.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/245249a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/245249a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/245249a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/245249a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/245249a0'


 

This table displays all metadata directly associated to this object as RDF triples.

184 TRIPLES      21 PREDICATES      75 URIs      66 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/245249a0 schema:about N1429dca73d3247c981f4188221a533ad
2 N21e3a2bf80ea4d1692207ad56378d714
3 N2d535b81e3cb466481790823bd9a292c
4 N37dbfd1daadf4b1baec68598da5a6bb9
5 N3f2e0cbde11348c0b51599aaeda153c9
6 N4dfa1328f1794ab4a6d09531f9868dfd
7 N51b1b0b024cb4feaa2855a76f87b563f
8 N52ca45f2e895475dad3d12b13bbab564
9 N59a1cc7acb894f3b9b420b4a169564e9
10 N5b54bcc6750145f6a370bd3c1f8a5e91
11 N633265ba113f4639bb6f720991dbf188
12 Nb2d06ee938a94e4b9a8dc42b064e402b
13 Nb41fc409b3c34fb6984d7fd5be592f45
14 Nbdfda13de8d34e5aab60708fc748b2e0
15 Nd196eb8ea82b40b88deb222b0af328ac
16 Nd604acc30c194592a38440b6ca8ef646
17 Nd95589b2472c47afa2139ecdd300307a
18 Nf0b2529e8c264bd5a69d98dc9f2337ff
19 anzsrc-for:11
20 anzsrc-for:1116
21 schema:author N0f661e1d055248d995c334db839a4bfc
22 schema:citation sg:pub.10.1038/236350a0
23 schema:datePublished 1973-10
24 schema:datePublishedReg 1973-10-01
25 schema:description Mast cells can be induced to secrete histamine by an ionophore, the action of which depends on the presence of calcium within a specific concentration range. The fact that labelled calcium can be seen to enter sensitized cells during histamine secretion in the presence of antigen suggests that the entry of calcium into the mast cell may be the trigger for the release of histamine.
26 schema:genre article
27 schema:isAccessibleForFree false
28 schema:isPartOf N7f2b4684224d4e6b997a52688151c18e
29 Nbd747b9b82ed44a8a1693507b320cbb1
30 sg:journal.1018957
31 schema:keywords action
32 antigen
33 calcium
34 calcium ionophore
35 calcium ions
36 cells
37 concentration range
38 entry
39 entry of calcium
40 fact
41 histamine
42 histamine secretion
43 ionophore
44 ions
45 mast cells
46 movement
47 physiological stimuli
48 presence
49 presence of antigen
50 presence of calcium
51 process
52 range
53 release
54 release of histamine
55 secretion
56 secretory process
57 sensitized cells
58 specific concentration range
59 stimuli
60 triggers
61 schema:name Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process
62 schema:pagination 249-251
63 schema:productId N31c1e8bcdbac47958a706b7460bd29c3
64 N91180a7251d14ec1a81b7f30e2476c03
65 Ne140027443ef41daace574449a5cda80
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020298262
67 https://doi.org/10.1038/245249a0
68 schema:sdDatePublished 2022-01-01T18:00
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N1c5983b1b5474658993e094fd9e78b57
71 schema:url https://doi.org/10.1038/245249a0
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0f661e1d055248d995c334db839a4bfc rdf:first sg:person.054312772.80
76 rdf:rest N6f205a5b729a41038a7f15284d2e81f2
77 N1429dca73d3247c981f4188221a533ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Antigens
79 rdf:type schema:DefinedTerm
80 N1c5983b1b5474658993e094fd9e78b57 schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N21e3a2bf80ea4d1692207ad56378d714 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Magnesium
84 rdf:type schema:DefinedTerm
85 N2d535b81e3cb466481790823bd9a292c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Calcium Radioisotopes
87 rdf:type schema:DefinedTerm
88 N31c1e8bcdbac47958a706b7460bd29c3 schema:name pubmed_id
89 schema:value 4126372
90 rdf:type schema:PropertyValue
91 N37dbfd1daadf4b1baec68598da5a6bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Histamine Release
93 rdf:type schema:DefinedTerm
94 N3f2e0cbde11348c0b51599aaeda153c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Ion Exchange
96 rdf:type schema:DefinedTerm
97 N4dfa1328f1794ab4a6d09531f9868dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Oxygen Consumption
99 rdf:type schema:DefinedTerm
100 N51b1b0b024cb4feaa2855a76f87b563f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Calcium
102 rdf:type schema:DefinedTerm
103 N52ca45f2e895475dad3d12b13bbab564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Cell Membrane Permeability
105 rdf:type schema:DefinedTerm
106 N59a1cc7acb894f3b9b420b4a169564e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Rats
108 rdf:type schema:DefinedTerm
109 N5b54bcc6750145f6a370bd3c1f8a5e91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Glycolysis
111 rdf:type schema:DefinedTerm
112 N633265ba113f4639bb6f720991dbf188 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Animals
114 rdf:type schema:DefinedTerm
115 N6f205a5b729a41038a7f15284d2e81f2 rdf:first sg:person.074063426.43
116 rdf:rest Ne02b6761c9ce4c2db37cd5291e7139c0
117 N7f2b4684224d4e6b997a52688151c18e schema:issueNumber 5423
118 rdf:type schema:PublicationIssue
119 N91180a7251d14ec1a81b7f30e2476c03 schema:name dimensions_id
120 schema:value pub.1020298262
121 rdf:type schema:PropertyValue
122 Nb2d06ee938a94e4b9a8dc42b064e402b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Carboxylic Acids
124 rdf:type schema:DefinedTerm
125 Nb41fc409b3c34fb6984d7fd5be592f45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Benzoates
127 rdf:type schema:DefinedTerm
128 Nbd747b9b82ed44a8a1693507b320cbb1 schema:volumeNumber 245
129 rdf:type schema:PublicationVolume
130 Nbdfda13de8d34e5aab60708fc748b2e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Mast Cells
132 rdf:type schema:DefinedTerm
133 Nd196eb8ea82b40b88deb222b0af328ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Strontium
135 rdf:type schema:DefinedTerm
136 Nd604acc30c194592a38440b6ca8ef646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Anti-Bacterial Agents
138 rdf:type schema:DefinedTerm
139 Nd95589b2472c47afa2139ecdd300307a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name In Vitro Techniques
141 rdf:type schema:DefinedTerm
142 Ne02b6761c9ce4c2db37cd5291e7139c0 rdf:first sg:person.012737166263.25
143 rdf:rest rdf:nil
144 Ne140027443ef41daace574449a5cda80 schema:name doi
145 schema:value 10.1038/245249a0
146 rdf:type schema:PropertyValue
147 Nf0b2529e8c264bd5a69d98dc9f2337ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mitochondria
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical Physiology
155 rdf:type schema:DefinedTerm
156 sg:journal.1018957 schema:issn 0028-0836
157 1476-4687
158 schema:name Nature
159 schema:publisher Springer Nature
160 rdf:type schema:Periodical
161 sg:person.012737166263.25 schema:affiliation grid-institutes:grid.439749.4
162 schema:familyName GOMPERTS
163 schema:givenName B. D.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012737166263.25
165 rdf:type schema:Person
166 sg:person.054312772.80 schema:affiliation grid-institutes:grid.83440.3b
167 schema:familyName FOREMAN
168 schema:givenName J. C.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.054312772.80
170 rdf:type schema:Person
171 sg:person.074063426.43 schema:affiliation grid-institutes:grid.83440.3b
172 schema:familyName MONGAR
173 schema:givenName J. L.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074063426.43
175 rdf:type schema:Person
176 sg:pub.10.1038/236350a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040337943
177 https://doi.org/10.1038/236350a0
178 rdf:type schema:CreativeWork
179 grid-institutes:grid.439749.4 schema:alternateName Department of Experimental Pathology, University College Hospital Medical School, WC1E 6JJ, London
180 schema:name Department of Experimental Pathology, University College Hospital Medical School, WC1E 6JJ, London
181 rdf:type schema:Organization
182 grid-institutes:grid.83440.3b schema:alternateName Department of Pharmacology, University College London, WC1E 6BT, London
183 schema:name Department of Pharmacology, University College London, WC1E 6BT, London
184 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...