Do the H-2 and T-Loci of the Mouse have a Function in the Haploid Phase of Sperm ? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1972-11

AUTHORS

MARY F. LYON, P. H. GLENISTER, SUSAN G. HAWKER

ABSTRACT

IT is still uncertain whether there is any gene activity in the haploid phase of mammalian sperm1, after meiosis in the maturing spermatids and spermatozoa. Two loci at which haploid activity possibly occurs in the mouse are the H-2 antigen locus and the T or brachyury locus, both situated near the centromeric end of chromosome 17 (linkage group IX)2. Evidence that the T-locus may act in the haploid phase comes from the effect of some alleles in distorting segregation ratios in the male3,4. Males heterozygous for certain recessive alleles give a very high proportion (up to 99%) of t-carrying young. Other alleles give an abnormally low proportion of young with the t-allele (10–20%) and yet others give a normal 1 : 1 ratio of + : t-carrying offspring. Although the mechanism of this effect is unknown it may well involve some action of the t-alleles concerned at the haploid stage. Antigens of the H-2 locus are expressed on mouse spermatozoa5. It has been claimed that both the human HL-A antigens and the mouse H-2 antigens on spermatozoa are produced by gene action at the haploid stage6, but for H-2 other authors have expressed doubt7. More... »

PAGES

152-153

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/240152b0

DOI

http://dx.doi.org/10.1038/240152b0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032791382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4564988


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