Acute Effect of Oral and Subcutaneous Administration of Monosodium Glutamate on the Arcuate Nucleus of the Hypothalamus in Mice and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-09

AUTHORS

R. M. BURDE, B. SCHAINKER, J. KAYES

ABSTRACT

RECENT reports by Olney that monosodium glutamate (MSG) can cause acute neuronal necrosis in the developing brain of mice1–3, rats1 and monkeys4, have been the subject of intensive debate5–11. Some people9,11 deny that a single subcutaneous dose of monosodium glutamate can produce any brain damage in infant rats. Although Arees and Mayer10 confirm the existence of a necrotic lesion in both mouse and rat brain they restrict the pathology to “microglial” cells. None of these investigators attempted actually to replicate Olney's methods but used entirely different methods of preservation and staining. More... »

PAGES

58-60

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/233058a0

DOI

http://dx.doi.org/10.1038/233058a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047281325

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12058742


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