Antigen Binding Cells in Tolerant Animals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1970-11

AUTHORS

OLOF SJÖBERG, ERNA MÖLLER

ABSTRACT

THE immune response involves the appearance of anti-body secreting cells as well as antigen binding cells. Antibody secreting cells can be counted in vitro using-Jerne and Nordin's local haemolysis in gel (LHG) assay1, and are then called plaque forming cells (PFC). Antigen binding cells can be recognized by their ability to bind particulate antigens such as sheep red cells (SRB) to their surfaces and have been named rosette forming cells (RFC)2,3. It is likely that RFC represent a mixture of antibody secreting cells and non-antibody secreting cells. Howard et al.4 studied the RFC response in the spleens of mice tolerant to pneumococcal polysaccharide. Although serum antibodies could not be seen in these animals a considerable number, larger, in fact, in “tolerant” than in optimally immunized animals, of RFC was found. They explained these findings on the basis that antibody secreting cells existed but that the humoral antibodies produced were neutralized extra-cellularly by persisting undegraded antigen. More... »

PAGES

780-781

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/228780a0

DOI

http://dx.doi.org/10.1038/228780a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014419721

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4919596


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