Temporal Characteristics of Amnesia induced by Protein Synthesis Inhibitor: Determination by Shock Level View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1970-11

AUTHORS

DAVID QUERMAIN, BRUCE S. MCEWEN

ABSTRACT

IT is widely accepted that cerebral protein synthesis is involved in “long term” but not “short term” memory. Evidence for this comes from experiments in which amnesia for a multiple-trial avoidance task is induced by administration of protein synthesis inhibitors before or shortly after training1–3. In mice4–6, the amnesia, which is permanent, does not appear until 3 h or more after training, leading to the notion of a “short term” memory, and is not produced if the criterion for learning is too severe. We have given mice a different learning task and used the protein synthesis inhibitor cycloheximide to induce amnesia that has such different characteristics as to warrant a re-evaluation of the hypothesis. More... »

PAGES

677-678

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/228677a0

DOI

http://dx.doi.org/10.1038/228677a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045394213

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5529057


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