Induction of a Mitochondrial DNA Polymerase in Tetrahymena View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1970-08

AUTHORS

O. WESTERGAARD, K. A. MARCKER, J. KEIDING

ABSTRACT

Tetrahymena pyriformis, strain GL, contains two different DNA polymerase activities—one major and one minor—which can be separated from one another by gel filtration on a ‘Sephadex G–200’ column1. Exposure of Tetrahymena to various forms of radiation or thymine starvation during growth leads to a rapid increase in the total DNA polymerase activity2,3. The appearance of this new activity is dependent on RNA and protein synthesis2,3. Subsequent experiments have revealed that the rise in total DNA polymerase activity in such cells is the result solely of a marked rise (about 35-fold) in the amount of the minor of the two polymerase activities1. The activity of the major DNA polymerase remains constant. Here we show that the induced DNA polymerase activity is associated with mitochondria, implying that the induced enzyme is a mitochondrial DNA polymerase. More... »

PAGES

708-710

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/227708a0

DOI

http://dx.doi.org/10.1038/227708a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023046677

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5432069


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