Neutralization of Graffi Leukaemia Virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1969-11

AUTHORS

J. P. LEVY, B. VARET, E. OPPENHEIM, J. C. LECLERC

ABSTRACT

GRAFFI leukaemia virus (GiLV) can be neutralized by specific antisera prepared either in rabbit1 or in mice2, but very little is known about the antigenic relations between GiLV and the other murine leukaemia viruses. Graffi et al. reported that an anti-AKR strain leukaemia rabbit anti-serum can neutralize GiLV3, while Steeves et al. observed that ariti-GiLV mice antisera are inefficient against Friend and Rauscher viruses4. The latter result contrasts with the existence of a cross-reacting “FMRGi” antigen at the membrane of leukaemic cells induced by Friend, Moloney, Rauscher and Graffi viruses5,6. Studies on the neutralization of GiLV reported here indicate that the antigens revealed by virus neutralization are different from FMRGi cellular antigen, and that an antigenic specificity of GiLV neutralization can be detected only by mice antisera. On the contrary, rabbit and rat antisera show a cross-reactivity between Gross, Graffi, Moloney and probably the other murine leukaemia viruses. More... »

PAGES

606

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/224606a0

DOI

http://dx.doi.org/10.1038/224606a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021855873

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4310360


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