Antibody-like Activity to the 2,4-Dinitrophenyl Group in Normal Human Sera View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1969-03

AUTHORS

MICHAEL W. BRANDRISS

ABSTRACT

VOLUNTEERS were injected with conjugates of 2,4-dinitro-phenyl–human serum albumin (DNP–HSA)1. Sixty per cent of subjects developed rising titres of agglutinating activity to DNP coupled red cells after injection, but most normal pre-immunization sera also had some agglutinating activity to DNP coupled cells. This activity was present in the fractions containing gamma globulin, was abolished by 2-mercaptoethanol, was specifically inhibited by the DNP haptenic determinant and was deficient in sera that were deficient in normal immunoglobulins—suggesting that most normal human sera contain antibody to the DNP group. More... »

PAGES

960-962

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/221960a0

DOI

http://dx.doi.org/10.1038/221960a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010450261

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5765511


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