2-(4-chlorophenyl)thiazol-4-ylacetic Acid (‘Myalex’): a New Compound with Anti-inflammatory, Analgesic and Antipyretic Activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1969-02

AUTHORS

W. HEPWORTH, B. B. NEWBOULD, D. S. PLATT, G. J. STACEY

ABSTRACT

THE use of adjuvant-induced arthritis in rats for the testing of compounds which may be of value in the treatment of rheumatoid arthritis in man1 has resulted in the discovery, in our laboratories, of two classes of compounds with different modes of action2–5. We wish to describe briefly the properties of a third class of compound6 which has recently been discovered using this laboratory model. More... »

PAGES

582-583

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/221582b0

DOI

http://dx.doi.org/10.1038/221582b0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017993482

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4978061


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analgesics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Temperature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chlorine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guinea Pigs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplorhini", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire"
          ], 
          "type": "Organization"
        }, 
        "familyName": "HEPWORTH", 
        "givenName": "W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire"
          ], 
          "type": "Organization"
        }, 
        "familyName": "NEWBOULD", 
        "givenName": "B. B.", 
        "id": "sg:person.077531610.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077531610.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire"
          ], 
          "type": "Organization"
        }, 
        "familyName": "PLATT", 
        "givenName": "D. S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire"
          ], 
          "type": "Organization"
        }, 
        "familyName": "STACEY", 
        "givenName": "G. J.", 
        "id": "sg:person.0113075110.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113075110.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/210638a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029791612", 
          "https://doi.org/10.1038/210638a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1969-02", 
    "datePublishedReg": "1969-02-01", 
    "description": "THE use of adjuvant-induced arthritis in rats for the testing of compounds which may be of value in the treatment of rheumatoid arthritis in man1 has resulted in the discovery, in our laboratories, of two classes of compounds with different modes of action2\u20135. We wish to describe briefly the properties of a third class of compound6 which has recently been discovered using this laboratory model.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/221582b0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5180", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "221"
      }
    ], 
    "keywords": [
      "rheumatoid arthritis", 
      "antipyretic activity", 
      "arthritis", 
      "testing of compounds", 
      "analgesics", 
      "rats", 
      "class of compounds", 
      "treatment", 
      "laboratory model", 
      "testing", 
      "activity", 
      "third class", 
      "new compounds", 
      "use", 
      "compounds", 
      "acid", 
      "laboratory", 
      "different modes", 
      "discovery", 
      "values", 
      "class", 
      "MAN1", 
      "model", 
      "mode", 
      "properties", 
      "action2", 
      "compound6"
    ], 
    "name": "2-(4-chlorophenyl)thiazol-4-ylacetic Acid (\u2018Myalex\u2019): a New Compound with Anti-inflammatory, Analgesic and Antipyretic Activity", 
    "pagination": "582-583", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017993482"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/221582b0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4978061"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/221582b0", 
      "https://app.dimensions.ai/details/publication/pub.1017993482"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_102.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/221582b0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/221582b0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/221582b0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/221582b0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/221582b0'


 

This table displays all metadata directly associated to this object as RDF triples.

167 TRIPLES      21 PREDICATES      68 URIs      59 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/221582b0 schema:about N1150dd808ffa4b46bcbbf8424bf98e1b
2 N2a67bc6df90747f1a63f3acd383e772d
3 N43cde081524f447e8683e305484b719b
4 N49b57cf5912640a38ede4e4c2d308ad5
5 N50a9b400e43f431d8603579dbb0e4f65
6 N587d61ed92394354acaef742697ed0de
7 N7f289b5b2e54433b9dc96144964618b3
8 N825d84b7dbbd494a92a8695580981d19
9 N9c0d945065694e7e9cb25eed482d502e
10 Na759aa4ad71f4051a7f7babb9926d45e
11 Nad3994dcf8de4c3cbffcd14b9238e5e6
12 Nc87f9ddb877b452798dcb4eeb7e18d49
13 Ncda97fc316c044a2aa346d8331349e31
14 Nce58507769294df38d2d78e6b4da1783
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N1fb69912088546c9886817d3592eef82
18 schema:citation sg:pub.10.1038/210638a0
19 schema:datePublished 1969-02
20 schema:datePublishedReg 1969-02-01
21 schema:description THE use of adjuvant-induced arthritis in rats for the testing of compounds which may be of value in the treatment of rheumatoid arthritis in man1 has resulted in the discovery, in our laboratories, of two classes of compounds with different modes of action2–5. We wish to describe briefly the properties of a third class of compound6 which has recently been discovered using this laboratory model.
22 schema:genre article
23 schema:isAccessibleForFree false
24 schema:isPartOf N03de170aa9104fad97855bd1773054d6
25 Nd040fbe9d89f445fb38180c75d89bbd0
26 sg:journal.1018957
27 schema:keywords MAN1
28 acid
29 action2
30 activity
31 analgesics
32 antipyretic activity
33 arthritis
34 class
35 class of compounds
36 compound6
37 compounds
38 different modes
39 discovery
40 laboratory
41 laboratory model
42 mode
43 model
44 new compounds
45 properties
46 rats
47 rheumatoid arthritis
48 testing
49 testing of compounds
50 third class
51 treatment
52 use
53 values
54 schema:name 2-(4-chlorophenyl)thiazol-4-ylacetic Acid (‘Myalex’): a New Compound with Anti-inflammatory, Analgesic and Antipyretic Activity
55 schema:pagination 582-583
56 schema:productId N3c2a258b26524c538aa66c89a4a8adfc
57 Ne2a59f5f6ee94cba9340c59ccf0daca4
58 Nfc437a4ce9934c9cba5ba3b8874ea5fd
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017993482
60 https://doi.org/10.1038/221582b0
61 schema:sdDatePublished 2021-12-01T19:01
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N40add04a9fe8416a94bd2ebfa3316392
64 schema:url https://doi.org/10.1038/221582b0
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0117f87724c44f6daf649c157751acfc schema:affiliation grid-institutes:None
69 schema:familyName PLATT
70 schema:givenName D. S.
71 rdf:type schema:Person
72 N03de170aa9104fad97855bd1773054d6 schema:volumeNumber 221
73 rdf:type schema:PublicationVolume
74 N1150dd808ffa4b46bcbbf8424bf98e1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Haplorhini
76 rdf:type schema:DefinedTerm
77 N1fb69912088546c9886817d3592eef82 rdf:first N841db5159f6b4c889f8b42dbf8aec068
78 rdf:rest Ncf6c49795f994c3ebfcb86878523b163
79 N2a67bc6df90747f1a63f3acd383e772d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Animals
81 rdf:type schema:DefinedTerm
82 N3c2a258b26524c538aa66c89a4a8adfc schema:name dimensions_id
83 schema:value pub.1017993482
84 rdf:type schema:PropertyValue
85 N40add04a9fe8416a94bd2ebfa3316392 schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N43cde081524f447e8683e305484b719b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Analgesics
89 rdf:type schema:DefinedTerm
90 N49b57cf5912640a38ede4e4c2d308ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Rats
92 rdf:type schema:DefinedTerm
93 N50a9b400e43f431d8603579dbb0e4f65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Body Temperature
95 rdf:type schema:DefinedTerm
96 N587d61ed92394354acaef742697ed0de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Dogs
98 rdf:type schema:DefinedTerm
99 N74f9b150f44442b0b3e6594c656f468a rdf:first sg:person.0113075110.72
100 rdf:rest rdf:nil
101 N7f289b5b2e54433b9dc96144964618b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Guinea Pigs
103 rdf:type schema:DefinedTerm
104 N825d84b7dbbd494a92a8695580981d19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Chlorine
106 rdf:type schema:DefinedTerm
107 N841db5159f6b4c889f8b42dbf8aec068 schema:affiliation grid-institutes:None
108 schema:familyName HEPWORTH
109 schema:givenName W.
110 rdf:type schema:Person
111 N9c0d945065694e7e9cb25eed482d502e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Phenols
113 rdf:type schema:DefinedTerm
114 Na759aa4ad71f4051a7f7babb9926d45e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Arthritis
116 rdf:type schema:DefinedTerm
117 Nad3994dcf8de4c3cbffcd14b9238e5e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Anti-Inflammatory Agents
119 rdf:type schema:DefinedTerm
120 Nc537ff9c80874524a3bf2568b9445cc0 rdf:first N0117f87724c44f6daf649c157751acfc
121 rdf:rest N74f9b150f44442b0b3e6594c656f468a
122 Nc87f9ddb877b452798dcb4eeb7e18d49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mice
124 rdf:type schema:DefinedTerm
125 Ncda97fc316c044a2aa346d8331349e31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Acetates
127 rdf:type schema:DefinedTerm
128 Nce58507769294df38d2d78e6b4da1783 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Thiazoles
130 rdf:type schema:DefinedTerm
131 Ncf6c49795f994c3ebfcb86878523b163 rdf:first sg:person.077531610.29
132 rdf:rest Nc537ff9c80874524a3bf2568b9445cc0
133 Nd040fbe9d89f445fb38180c75d89bbd0 schema:issueNumber 5180
134 rdf:type schema:PublicationIssue
135 Ne2a59f5f6ee94cba9340c59ccf0daca4 schema:name doi
136 schema:value 10.1038/221582b0
137 rdf:type schema:PropertyValue
138 Nfc437a4ce9934c9cba5ba3b8874ea5fd schema:name pubmed_id
139 schema:value 4978061
140 rdf:type schema:PropertyValue
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
145 schema:name Clinical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1018957 schema:issn 0028-0836
148 1476-4687
149 schema:name Nature
150 schema:publisher Springer Nature
151 rdf:type schema:Periodical
152 sg:person.0113075110.72 schema:affiliation grid-institutes:None
153 schema:familyName STACEY
154 schema:givenName G. J.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113075110.72
156 rdf:type schema:Person
157 sg:person.077531610.29 schema:affiliation grid-institutes:None
158 schema:familyName NEWBOULD
159 schema:givenName B. B.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077531610.29
161 rdf:type schema:Person
162 sg:pub.10.1038/210638a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029791612
163 https://doi.org/10.1038/210638a0
164 rdf:type schema:CreativeWork
165 grid-institutes:None schema:alternateName Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire
166 schema:name Research Department, Imperial Chemical Industries, Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire
167 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...