Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-07-08

AUTHORS

Takashi Adachi-Yamada, Konomi Fujimura-Kamada, Yasuyoshi Nishida, Kunihiro Matsumoto

ABSTRACT

Distinct and evolutionarily conserved signal-transduction cascades mediate the survival or death of cells during development. The c-Jun amino-terminal kinases (JNKs) of the mitogen-activated protein kinase superfamily are involved in apoptotic signalling in various cultured cells1. However, the role of the JNK pathway in development is less well understood. In Drosophila, Decapentaplegic (Dpp; a homologue of transforming growth factor-β) and Wingless (Wg; a Wnt homologue) proteins are secretory morphogens that act cooperatively to induce formation of the proximodistal axis of appendages2,3,4,5,6,7. Here we show that either decreased Dpp signalling in the distal wing cells or increased Dpp signalling in the proximal wing cells causes apoptosis. Inappropriate levels of Dpp signalling lead to aberrant morphogenesis in the respective wing zones, and these apoptotic zones are also determined by the strength of the Wg signal. Our results indicate that distortion of the positional information determined by Dpp and Wg signalling gradients leads to activation of the JNK apoptotic pathway, and the consequent induction of cell death thereby maintains normal morphogenesis. More... »

PAGES

166-169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/22112

DOI

http://dx.doi.org/10.1038/22112

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053678680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10408443


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acridine Orange", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insect Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "JNK Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoprotein Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Box Domain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wings, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt1 Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adachi-Yamada", 
        "givenName": "Takashi", 
        "id": "sg:person.01136601072.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136601072.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimura-Kamada", 
        "givenName": "Konomi", 
        "id": "sg:person.0640030323.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640030323.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishida", 
        "givenName": "Yasuyoshi", 
        "id": "sg:person.010644736405.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010644736405.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Kunihiro", 
        "id": "sg:person.015113745762.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015113745762.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/381387a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001004981", 
          "https://doi.org/10.1038/381387a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-07-08", 
    "datePublishedReg": "1999-07-08", 
    "description": "Distinct and evolutionarily conserved signal-transduction cascades mediate the survival or death of cells during development. The c-Jun amino-terminal kinases (JNKs) of the mitogen-activated protein kinase superfamily are involved in apoptotic signalling in various cultured cells1. However, the role of the JNK pathway in development is less well understood. In Drosophila, Decapentaplegic (Dpp; a homologue of transforming growth factor-\u03b2) and Wingless (Wg; a Wnt homologue) proteins are secretory morphogens that act cooperatively to induce formation of the proximodistal axis of appendages2,3,4,5,6,7. Here we show that either decreased Dpp signalling in the distal wing cells or increased Dpp signalling in the proximal wing cells causes apoptosis. Inappropriate levels of Dpp signalling lead to aberrant morphogenesis in the respective wing zones, and these apoptotic zones are also determined by the strength of the Wg signal. Our results indicate that distortion of the positional information determined by Dpp and Wg signalling gradients leads to activation of the JNK apoptotic pathway, and the consequent induction of cell death thereby maintains normal morphogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/22112", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6740", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "400"
      }
    ], 
    "keywords": [
      "Jun amino-terminal kinase", 
      "wing cells", 
      "mitogen-activated protein kinase", 
      "JNK-dependent apoptosis", 
      "amino-terminal kinase", 
      "death of cells", 
      "JNK apoptotic pathway", 
      "wingless protein", 
      "Wg signal", 
      "Drosophila wing", 
      "aberrant morphogenesis", 
      "protein kinase", 
      "normal morphogenesis", 
      "apoptotic signaling", 
      "apoptotic pathway", 
      "JNK pathway", 
      "proximodistal axis", 
      "cell death", 
      "positional information", 
      "morphogenesis", 
      "consequent induction", 
      "kinase", 
      "DPP", 
      "apoptosis", 
      "pathway", 
      "cells", 
      "Drosophila", 
      "decapentaplegic", 
      "morphogens", 
      "signaling", 
      "protein", 
      "Cells1", 
      "activation", 
      "induction", 
      "WG", 
      "death", 
      "development", 
      "role", 
      "survival", 
      "wing", 
      "gradient", 
      "formation", 
      "zone", 
      "signals", 
      "levels", 
      "inappropriate levels", 
      "information", 
      "axis", 
      "lead", 
      "results", 
      "strength", 
      "distortion", 
      "cultured cells1", 
      "secretory morphogens", 
      "distal wing cells", 
      "proximal wing cells", 
      "respective wing zones", 
      "wing zones", 
      "apoptotic zones", 
      "proximodistal information"
    ], 
    "name": "Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing", 
    "pagination": "166-169", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053678680"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/22112"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10408443"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/22112", 
      "https://app.dimensions.ai/details/publication/pub.1053678680"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_347.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/22112"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/22112'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/22112'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/22112'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/22112'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      22 PREDICATES      112 URIs      103 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/22112 schema:about N12d2a336eacf486ca7a1814487bff7db
2 N12ef714492e64a848756da3f922ccc5a
3 N36a29acf38ce4d379e6a0474571060cf
4 N46d34a7516874096989a9e4f46cb7e0f
5 N5de353d5ffd74453a28d4c21e1d5752f
6 N625bcc4aac66472aa17592bbc959bce8
7 N8729b23889cb49d991b223ff696f4eba
8 N89b4a9114c614fb499d30f6bf86438a1
9 N8cd52de1f3314721886e3c15ae736fbb
10 N9b9be088a4be48bcbacd05a0ee63fb6f
11 Na0167646c5ee43238dcbdf19ec47ec5b
12 Nb0e6c19653204ae5b3f8291c07e164da
13 Nb70f5dff6c7f425a8f2af5248d403282
14 Nc95ee34e4b5744bfb8ad5ab9ca7389cd
15 Ncd08679b5f854526be4d99a9aa888ec7
16 Nd071557a63db478e9e26cc3afaaecc8f
17 Nd2f3cc870edb4111b8913ce73bb95130
18 Nd9afe69e08464204b5d307214ae7c3f7
19 Ne201f9dbd5f04a9ca2a068ce9752e12f
20 Ne3a1e2b8cbb643a78333c83c1330264e
21 Nea2a1b8205db4ebd8c237b93c393a609
22 Nf11bedebc832473cac5bb21c71278da3
23 Nf25d18310c934df98472fc0f4ec6158f
24 Nfad09bd8bc6143598a163f88d9fae1f0
25 Nffd32728ee024302b0fec432c50d093f
26 anzsrc-for:06
27 anzsrc-for:0601
28 schema:author N74deff8c972341c7956daeea5d8b6b74
29 schema:citation sg:pub.10.1038/381387a0
30 schema:datePublished 1999-07-08
31 schema:datePublishedReg 1999-07-08
32 schema:description Distinct and evolutionarily conserved signal-transduction cascades mediate the survival or death of cells during development. The c-Jun amino-terminal kinases (JNKs) of the mitogen-activated protein kinase superfamily are involved in apoptotic signalling in various cultured cells1. However, the role of the JNK pathway in development is less well understood. In Drosophila, Decapentaplegic (Dpp; a homologue of transforming growth factor-β) and Wingless (Wg; a Wnt homologue) proteins are secretory morphogens that act cooperatively to induce formation of the proximodistal axis of appendages2,3,4,5,6,7. Here we show that either decreased Dpp signalling in the distal wing cells or increased Dpp signalling in the proximal wing cells causes apoptosis. Inappropriate levels of Dpp signalling lead to aberrant morphogenesis in the respective wing zones, and these apoptotic zones are also determined by the strength of the Wg signal. Our results indicate that distortion of the positional information determined by Dpp and Wg signalling gradients leads to activation of the JNK apoptotic pathway, and the consequent induction of cell death thereby maintains normal morphogenesis.
33 schema:genre article
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf N227c3ca63f13425784192448afcd144a
37 N9184fdf33f644cff81159cbc1f0338ff
38 sg:journal.1018957
39 schema:keywords Cells1
40 DPP
41 Drosophila
42 Drosophila wing
43 JNK apoptotic pathway
44 JNK pathway
45 JNK-dependent apoptosis
46 Jun amino-terminal kinase
47 WG
48 Wg signal
49 aberrant morphogenesis
50 activation
51 amino-terminal kinase
52 apoptosis
53 apoptotic pathway
54 apoptotic signaling
55 apoptotic zones
56 axis
57 cell death
58 cells
59 consequent induction
60 cultured cells1
61 death
62 death of cells
63 decapentaplegic
64 development
65 distal wing cells
66 distortion
67 formation
68 gradient
69 inappropriate levels
70 induction
71 information
72 kinase
73 lead
74 levels
75 mitogen-activated protein kinase
76 morphogenesis
77 morphogens
78 normal morphogenesis
79 pathway
80 positional information
81 protein
82 protein kinase
83 proximal wing cells
84 proximodistal axis
85 proximodistal information
86 respective wing zones
87 results
88 role
89 secretory morphogens
90 signaling
91 signals
92 strength
93 survival
94 wing
95 wing cells
96 wing zones
97 wingless protein
98 zone
99 schema:name Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
100 schema:pagination 166-169
101 schema:productId N6a3aa67ca5074b4c97fe493c079e3bc8
102 N7ef491506b734e9aa190b6b56a634812
103 Nc730e1f45b3c450a93357f4c4ea2daf7
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053678680
105 https://doi.org/10.1038/22112
106 schema:sdDatePublished 2022-01-01T18:11
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N20f8d827e9df4ea7af0347094fcbfd5d
109 schema:url https://doi.org/10.1038/22112
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N12d2a336eacf486ca7a1814487bff7db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Signal Transduction
115 rdf:type schema:DefinedTerm
116 N12ef714492e64a848756da3f922ccc5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name MAP Kinase Kinase 4
118 rdf:type schema:DefinedTerm
119 N20f8d827e9df4ea7af0347094fcbfd5d schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 N227c3ca63f13425784192448afcd144a schema:issueNumber 6740
122 rdf:type schema:PublicationIssue
123 N36a29acf38ce4d379e6a0474571060cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 N46d34a7516874096989a9e4f46cb7e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Up-Regulation
128 rdf:type schema:DefinedTerm
129 N5de353d5ffd74453a28d4c21e1d5752f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Down-Regulation
131 rdf:type schema:DefinedTerm
132 N625bcc4aac66472aa17592bbc959bce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Apoptosis
134 rdf:type schema:DefinedTerm
135 N6a3aa67ca5074b4c97fe493c079e3bc8 schema:name pubmed_id
136 schema:value 10408443
137 rdf:type schema:PropertyValue
138 N74deff8c972341c7956daeea5d8b6b74 rdf:first sg:person.01136601072.37
139 rdf:rest N79747389a1cf45508a52b2e1588103e6
140 N79747389a1cf45508a52b2e1588103e6 rdf:first sg:person.0640030323.59
141 rdf:rest Na23741a7a2a0406abbc31e29a1b309f1
142 N7ef491506b734e9aa190b6b56a634812 schema:name dimensions_id
143 schema:value pub.1053678680
144 rdf:type schema:PropertyValue
145 N8729b23889cb49d991b223ff696f4eba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Wnt1 Protein
147 rdf:type schema:DefinedTerm
148 N89b4a9114c614fb499d30f6bf86438a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Phosphoprotein Phosphatases
150 rdf:type schema:DefinedTerm
151 N8cd52de1f3314721886e3c15ae736fbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Receptors, Cell Surface
153 rdf:type schema:DefinedTerm
154 N9184fdf33f644cff81159cbc1f0338ff schema:volumeNumber 400
155 rdf:type schema:PublicationVolume
156 N94c85bbeaba84d16906098deb7fbe01a rdf:first sg:person.015113745762.58
157 rdf:rest rdf:nil
158 N9b9be088a4be48bcbacd05a0ee63fb6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Mutation
160 rdf:type schema:DefinedTerm
161 Na0167646c5ee43238dcbdf19ec47ec5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Mitogen-Activated Protein Kinase Kinases
163 rdf:type schema:DefinedTerm
164 Na23741a7a2a0406abbc31e29a1b309f1 rdf:first sg:person.010644736405.46
165 rdf:rest N94c85bbeaba84d16906098deb7fbe01a
166 Nb0e6c19653204ae5b3f8291c07e164da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Acridine Orange
168 rdf:type schema:DefinedTerm
169 Nb70f5dff6c7f425a8f2af5248d403282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Protein-Serine-Threonine Kinases
171 rdf:type schema:DefinedTerm
172 Nc730e1f45b3c450a93357f4c4ea2daf7 schema:name doi
173 schema:value 10.1038/22112
174 rdf:type schema:PropertyValue
175 Nc95ee34e4b5744bfb8ad5ab9ca7389cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Proto-Oncogene Proteins
177 rdf:type schema:DefinedTerm
178 Ncd08679b5f854526be4d99a9aa888ec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Nerve Tissue Proteins
180 rdf:type schema:DefinedTerm
181 Nd071557a63db478e9e26cc3afaaecc8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Animals, Genetically Modified
183 rdf:type schema:DefinedTerm
184 Nd2f3cc870edb4111b8913ce73bb95130 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name T-Box Domain Proteins
186 rdf:type schema:DefinedTerm
187 Nd9afe69e08464204b5d307214ae7c3f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Insect Proteins
189 rdf:type schema:DefinedTerm
190 Ne201f9dbd5f04a9ca2a068ce9752e12f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Protein Kinases
192 rdf:type schema:DefinedTerm
193 Ne3a1e2b8cbb643a78333c83c1330264e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Wings, Animal
195 rdf:type schema:DefinedTerm
196 Nea2a1b8205db4ebd8c237b93c393a609 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name JNK Mitogen-Activated Protein Kinases
198 rdf:type schema:DefinedTerm
199 Nf11bedebc832473cac5bb21c71278da3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Drosophila
201 rdf:type schema:DefinedTerm
202 Nf25d18310c934df98472fc0f4ec6158f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Drosophila Proteins
204 rdf:type schema:DefinedTerm
205 Nfad09bd8bc6143598a163f88d9fae1f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name DNA-Binding Proteins
207 rdf:type schema:DefinedTerm
208 Nffd32728ee024302b0fec432c50d093f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Enzyme Activation
210 rdf:type schema:DefinedTerm
211 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biological Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
215 schema:name Biochemistry and Cell Biology
216 rdf:type schema:DefinedTerm
217 sg:journal.1018957 schema:issn 0028-0836
218 1476-4687
219 schema:name Nature
220 schema:publisher Springer Nature
221 rdf:type schema:Periodical
222 sg:person.010644736405.46 schema:affiliation grid-institutes:grid.27476.30
223 schema:familyName Nishida
224 schema:givenName Yasuyoshi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010644736405.46
226 rdf:type schema:Person
227 sg:person.01136601072.37 schema:affiliation grid-institutes:grid.27476.30
228 schema:familyName Adachi-Yamada
229 schema:givenName Takashi
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136601072.37
231 rdf:type schema:Person
232 sg:person.015113745762.58 schema:affiliation grid-institutes:grid.27476.30
233 schema:familyName Matsumoto
234 schema:givenName Kunihiro
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015113745762.58
236 rdf:type schema:Person
237 sg:person.0640030323.59 schema:affiliation grid-institutes:grid.27476.30
238 schema:familyName Fujimura-Kamada
239 schema:givenName Konomi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640030323.59
241 rdf:type schema:Person
242 sg:pub.10.1038/381387a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001004981
243 https://doi.org/10.1038/381387a0
244 rdf:type schema:CreativeWork
245 grid-institutes:grid.27476.30 schema:alternateName Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan
246 schema:name Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, 464-8602, Chikusa-ku, Nagoya, Japan
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...