Molecular Pathology of Human Haemoglobin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1968-08

AUTHORS

M. F. PERUTZ, H. LEHMANN

ABSTRACT

The haemoglobin molecule is insensitive to replacements of most amino-acid residues on its surface, but extremely sensitive to even quite small alterations of internal non-polar contacts, especially those near the haems. Replacements at the contacts between α and β-subunits affect respiratory function.

PAGES

902-909

References to SciGraph publications

  • 1967-05. Haemoglobin Genova: β28 (B10) Leucine→Proline in NATURE
  • 1959-08. A Terminal Peptide Sequence of Human Hæmoglobin? in NATURE
  • 1950-10. State of Hæmoglobin in Sickle-Cell Anæmia in NATURE
  • 1966-11. Haemoglobin J Cape Town—α2 92 Arginine→Glutamine β2 in NATURE
  • 1967-03. Haemoglobin New York in NATURE
  • 1965-11. Three Haemoglobins K: Woolwich, an Abnormal, Cameroon and Ibadan, Two Unusual Variants of Human Haemoglobin A in NATURE
  • 1967-08. Haemoglobin Sydney: β67 (EII) Valine→ Alanine : an Emerging Pattern of Unstable Haemoglobins in NATURE
  • 1968-06. Abnormal Haem Binding and Globin SH Group Blockade in Unstable Haemoglobins in NATURE
  • 1959-09. Abnormal Human Hæmoglobins: Human Hæmoglobin E: the Chemical Effect of Gene Mutation in NATURE
  • 1968-06. Compensation in Haemolytic Anaemias caused by Abnormal Haemoglobins in NATURE
  • 1968-07. Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution : (I) X-ray Analysis in NATURE
  • 1967-07. Oxygen Binding by Haemoglobin J-Cape Town (α2 92 Arg → Gln) in NATURE
  • 1968-07. Diffusion of Antibiotics from Plasma into Prostatic Fluid in NATURE
  • 1968-03. Haemoglobin Torino – α43 (CDI) Phenylalanine→Valine in NATURE
  • 1967-12. The suppression of Haemoglobin E synthesis in HUMANGENETIK
  • 1968-01. Japanese Haemoglobin Variant in NATURE
  • 1966-05. Haemoglobin Köln (β–98 Valine → Methionine): An Unstable Protein Causing Inclusion-Body Anaemia in NATURE
  • 1965-07. Abnormal Haemoglobins and the Genetic Code in NATURE
  • 1966-01. Hemoglobin tacoma — A β-chain variant in HUMANGENETIK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/219902a0

    DOI

    http://dx.doi.org/10.1038/219902a0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5691676


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