Antagonism by Fenamates of Prostaglandin F2α and of Slow Reacting Substance on Human Bronchial Muscle View Full Text


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Article Info

DATE

1968-08

AUTHORS

H. O. J. COLLIER, W. J. F. SWEATMAN

ABSTRACT

HISTAMINE, slow reacting substance in anaphylaxis (SRS-A) and prostaglandin F2α (PGF2α) are among substances obtained from lungs that contract human isolated bronchial muscle1–4. Fenamates antagonize bronchoconstriction induced by SRS-A but not that induced by histamine, and they lessen anaphylactic bronchoconstriction in the guinea-pig in vivo5–7. In view of the possibility, arising from these observations, that fenamates might be useful clinically against pathological bronchoconstriction, we explored how far meclofenamate (sodium N-(2,6-dichloro-m-tolyl) anthranilate)8 and flufenamate (sodium N-(α,α,α-trifluoro-m-toryl) anthranilate)9 antagonized the contraction of human isolated bronchial muscle induced by histamine, SRS-A or PGF2α. More... »

PAGES

864-865

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/219864a0

DOI

http://dx.doi.org/10.1038/219864a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036319204


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