Diffusion of Antibiotics from Plasma into Prostatic Fluid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1968-07

AUTHORS

D. G. WINNINGHAM, N. J. NEMOY, T. A. STAMEY

ABSTRACT

Of nine antimicrobial agents introduced intravenously into sixteen dogs, only the basic macrolides erythromycin and oleandomycin readily crossed the prostatic epithelium into the prostatic fluid. A suitable drug for curing chronic bacterial prostatitis with bladder bacteriuria must be lipid soluble, have a pKa of 8.6 or more, and have optimal activity against Gram-negative bacteria at pH 6.6. More... »

PAGES

139

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/219139a0

DOI

http://dx.doi.org/10.1038/219139a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019939571

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4298194


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