New Hypothesis of Insulin Secretion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1968-09

AUTHORS

PAUL E. LACY, SIMON L. HOWELL, DONALD A. YOUNG, C. JOAN FINK

ABSTRACT

RELEASE of insulin from beta cells of the islets of Langer-hans occurs as a result of the movement of secretory granules to the surface of the cells. Here the membranous sacs encasing the granules fuse with the plasma membrane, rupture and liberate the granules into the extracellular space1. This process is called emiocytosis. Although glucose represents the most important physiologic stimulus for the release of insulin from the beta cells, it has been shown recently that the rates of secretion of insulin are also altered in the presence of a wide variety of other agents2. So far, little information is available concerning the relationship between the biochemical effects of these agents and the process of emiocytosis. We suggest here a working hypothesis for the events which occur between biochemical stimulation and the liberation of secretory granules into the extracellular space. More... »

PAGES

1177-1179

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2191177a0

DOI

http://dx.doi.org/10.1038/2191177a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027482653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4877537


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colchicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Secretion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Washington University School of Medicine, St Louis, Missouri", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology, Washington University School of Medicine, St Louis, Missouri"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LACY", 
        "givenName": "PAUL E.", 
        "id": "sg:person.0643330755.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643330755.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Washington University School of Medicine, St Louis, Missouri", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology, Washington University School of Medicine, St Louis, Missouri"
          ], 
          "type": "Organization"
        }, 
        "familyName": "HOWELL", 
        "givenName": "SIMON L.", 
        "id": "sg:person.067771434.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067771434.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Washington University School of Medicine, St Louis, Missouri", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology, Washington University School of Medicine, St Louis, Missouri"
          ], 
          "type": "Organization"
        }, 
        "familyName": "YOUNG", 
        "givenName": "DONALD A.", 
        "id": "sg:person.073632534.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073632534.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Washington University School of Medicine, St Louis, Missouri", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology, Washington University School of Medicine, St Louis, Missouri"
          ], 
          "type": "Organization"
        }, 
        "familyName": "FINK", 
        "givenName": "C. JOAN", 
        "id": "sg:person.01120045631.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120045631.22"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1968-09", 
    "datePublishedReg": "1968-09-01", 
    "description": "RELEASE of insulin from beta cells of the islets of Langer-hans occurs as a result of the movement of secretory granules to the surface of the cells. Here the membranous sacs encasing the granules fuse with the plasma membrane, rupture and liberate the granules into the extracellular space1. This process is called emiocytosis. Although glucose represents the most important physiologic stimulus for the release of insulin from the beta cells, it has been shown recently that the rates of secretion of insulin are also altered in the presence of a wide variety of other agents2. So far, little information is available concerning the relationship between the biochemical effects of these agents and the process of emiocytosis. We suggest here a working hypothesis for the events which occur between biochemical stimulation and the liberation of secretory granules into the extracellular space.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/2191177a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5159", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "219"
      }
    ], 
    "keywords": [
      "release of insulin", 
      "beta cells", 
      "secretory granules", 
      "rate of secretion", 
      "insulin secretion", 
      "insulin", 
      "biochemical effects", 
      "physiologic stimuli", 
      "secretion", 
      "extracellular space", 
      "little information", 
      "emiocytosis", 
      "cells", 
      "membranous sac", 
      "granules", 
      "release", 
      "islets", 
      "stimulation", 
      "biochemical stimulation", 
      "sac", 
      "glucose", 
      "rupture", 
      "plasma membrane", 
      "new hypothesis", 
      "stimuli", 
      "hypothesis", 
      "agents", 
      "wide variety", 
      "rate", 
      "events", 
      "effect", 
      "presence", 
      "membrane", 
      "relationship", 
      "movement", 
      "results", 
      "variety", 
      "information", 
      "liberation", 
      "process", 
      "space1", 
      "surface", 
      "space"
    ], 
    "name": "New Hypothesis of Insulin Secretion", 
    "pagination": "1177-1179", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027482653"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/2191177a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4877537"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/2191177a0", 
      "https://app.dimensions.ai/details/publication/pub.1027482653"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_96.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/2191177a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/2191177a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/2191177a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/2191177a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/2191177a0'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      20 PREDICATES      78 URIs      70 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/2191177a0 schema:about N0db3d1cdf1f840a19fd3322dae33d9e2
2 N1c9c998f42a24d72b950040c162441a0
3 N1cd202653e7e48dbac09be2d53222259
4 N3d4d8267e6144460bade4285cd453bec
5 N3d63bbe821ec4866b0708837fa981383
6 N6502b9feb92f4ba982b12debf03eb8b0
7 N6a5fba3a2db445749d662141bd6b12b1
8 Naa519bd7bc6b444684caaf4201435ff8
9 Nade3da3bf50b466ebcab37b2392d47b4
10 anzsrc-for:06
11 anzsrc-for:0601
12 schema:author Nf0bf412a8c0c4f01b13b1c3b6a9b0a96
13 schema:datePublished 1968-09
14 schema:datePublishedReg 1968-09-01
15 schema:description RELEASE of insulin from beta cells of the islets of Langer-hans occurs as a result of the movement of secretory granules to the surface of the cells. Here the membranous sacs encasing the granules fuse with the plasma membrane, rupture and liberate the granules into the extracellular space1. This process is called emiocytosis. Although glucose represents the most important physiologic stimulus for the release of insulin from the beta cells, it has been shown recently that the rates of secretion of insulin are also altered in the presence of a wide variety of other agents2. So far, little information is available concerning the relationship between the biochemical effects of these agents and the process of emiocytosis. We suggest here a working hypothesis for the events which occur between biochemical stimulation and the liberation of secretory granules into the extracellular space.
16 schema:genre article
17 schema:isAccessibleForFree false
18 schema:isPartOf N5da1af2a1cd74b75bb4575342798126e
19 Nc4ecdb6799e74f2db5adaa4cd4f81ec0
20 sg:journal.1018957
21 schema:keywords agents
22 beta cells
23 biochemical effects
24 biochemical stimulation
25 cells
26 effect
27 emiocytosis
28 events
29 extracellular space
30 glucose
31 granules
32 hypothesis
33 information
34 insulin
35 insulin secretion
36 islets
37 liberation
38 little information
39 membrane
40 membranous sac
41 movement
42 new hypothesis
43 physiologic stimuli
44 plasma membrane
45 presence
46 process
47 rate
48 rate of secretion
49 relationship
50 release
51 release of insulin
52 results
53 rupture
54 sac
55 secretion
56 secretory granules
57 space
58 space1
59 stimulation
60 stimuli
61 surface
62 variety
63 wide variety
64 schema:name New Hypothesis of Insulin Secretion
65 schema:pagination 1177-1179
66 schema:productId N8929ac32ba4a4790ae20a02e2429af21
67 Ncf4a9b38e6464f1bb5205e5566e251c2
68 Nfbe2b45e55be4f4794f199e4e9584345
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027482653
70 https://doi.org/10.1038/2191177a0
71 schema:sdDatePublished 2022-12-01T06:45
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher Nf44cf150e9d747ccacada433f6a01c21
74 schema:url https://doi.org/10.1038/2191177a0
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0589980b5a6f4312a59dc778f5948d31 rdf:first sg:person.073632534.22
79 rdf:rest N15c0f5bd7fc34ac099fd91ad33e7f4e6
80 N0db3d1cdf1f840a19fd3322dae33d9e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Rats
82 rdf:type schema:DefinedTerm
83 N15c0f5bd7fc34ac099fd91ad33e7f4e6 rdf:first sg:person.01120045631.22
84 rdf:rest rdf:nil
85 N1c9c998f42a24d72b950040c162441a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Islets of Langerhans
87 rdf:type schema:DefinedTerm
88 N1cd202653e7e48dbac09be2d53222259 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Glucose
90 rdf:type schema:DefinedTerm
91 N3d4d8267e6144460bade4285cd453bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Microscopy, Electron
93 rdf:type schema:DefinedTerm
94 N3d63bbe821ec4866b0708837fa981383 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Animals
96 rdf:type schema:DefinedTerm
97 N4aa21b592eae446ba6afd35673b76c0c rdf:first sg:person.067771434.72
98 rdf:rest N0589980b5a6f4312a59dc778f5948d31
99 N5da1af2a1cd74b75bb4575342798126e schema:issueNumber 5159
100 rdf:type schema:PublicationIssue
101 N6502b9feb92f4ba982b12debf03eb8b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Colchicine
103 rdf:type schema:DefinedTerm
104 N6a5fba3a2db445749d662141bd6b12b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Organoids
106 rdf:type schema:DefinedTerm
107 N8929ac32ba4a4790ae20a02e2429af21 schema:name doi
108 schema:value 10.1038/2191177a0
109 rdf:type schema:PropertyValue
110 Naa519bd7bc6b444684caaf4201435ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Insulin Secretion
112 rdf:type schema:DefinedTerm
113 Nade3da3bf50b466ebcab37b2392d47b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Insulin
115 rdf:type schema:DefinedTerm
116 Nc4ecdb6799e74f2db5adaa4cd4f81ec0 schema:volumeNumber 219
117 rdf:type schema:PublicationVolume
118 Ncf4a9b38e6464f1bb5205e5566e251c2 schema:name dimensions_id
119 schema:value pub.1027482653
120 rdf:type schema:PropertyValue
121 Nf0bf412a8c0c4f01b13b1c3b6a9b0a96 rdf:first sg:person.0643330755.26
122 rdf:rest N4aa21b592eae446ba6afd35673b76c0c
123 Nf44cf150e9d747ccacada433f6a01c21 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 Nfbe2b45e55be4f4794f199e4e9584345 schema:name pubmed_id
126 schema:value 4877537
127 rdf:type schema:PropertyValue
128 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
129 schema:name Biological Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
132 schema:name Biochemistry and Cell Biology
133 rdf:type schema:DefinedTerm
134 sg:journal.1018957 schema:issn 0028-0836
135 1476-4687
136 schema:name Nature
137 schema:publisher Springer Nature
138 rdf:type schema:Periodical
139 sg:person.01120045631.22 schema:affiliation grid-institutes:grid.4367.6
140 schema:familyName FINK
141 schema:givenName C. JOAN
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120045631.22
143 rdf:type schema:Person
144 sg:person.0643330755.26 schema:affiliation grid-institutes:grid.4367.6
145 schema:familyName LACY
146 schema:givenName PAUL E.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643330755.26
148 rdf:type schema:Person
149 sg:person.067771434.72 schema:affiliation grid-institutes:grid.4367.6
150 schema:familyName HOWELL
151 schema:givenName SIMON L.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067771434.72
153 rdf:type schema:Person
154 sg:person.073632534.22 schema:affiliation grid-institutes:grid.4367.6
155 schema:familyName YOUNG
156 schema:givenName DONALD A.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073632534.22
158 rdf:type schema:Person
159 grid-institutes:grid.4367.6 schema:alternateName Department of Pathology, Washington University School of Medicine, St Louis, Missouri
160 schema:name Department of Pathology, Washington University School of Medicine, St Louis, Missouri
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...