Receptor Molecule for Oestrogens from Rat Uterus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1968-06

AUTHORS

G. A. PUCA, F. BRESCIANI

ABSTRACT

RECENT research (see refs. 1–3) has shown that 17β-oestradiol is specifically taken up and retained, without detectable chemical transformation, by uterus, vagina, adenohypophysis, mammary gland4 and hypothalamus5. In contrast, other organs rapidly release or transform it. In target tissues most of the hormone is found in the nuclear fraction—up to 80 per cent, depending on the homogenization conditions—and the rest is mostly in the 105,000g supernatant6–10. Toft and Gorsky11,12 found that the hormone in the supernatant is bound in larger part to a macromolecule (9.5S) which, at least in part, consists of protein and has the properties of a specific receptor for oestrogens, that is, it shows a high affinity and specificity for oestrogenic molecules. More... »

PAGES

967-969

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/218967a0

DOI

http://dx.doi.org/10.1038/218967a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008011962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5681242


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