Effects of Vasopressin, Theophylline and Cyclic Adenosine Monophosphate on Short-circuit Current across Isolated Rabbit Ileal Mucosa View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1968-02

AUTHORS

MICHAEL FIELD, GERALD R. PLOTKIN, WILLIAM SILEN

ABSTRACT

VASOPRESSIN causes rapid, equal increases in short-circuit current (Isc) and rate of transport of sodium when added to the serosal surface of frog skin or toad bladder1,2. Several investigators have presented convincing evidence that this alteration in the active transport of sodium is primarily, if not entirely, a consequence of increased passive permeability of the mucosal surface to sodium, as well as to other small hydrophilic solutes3–5. Adenosine-3′,5′-monophosphate (cyclic AMP) and theophylline have been shown to mimic the effects of vasopressin on Isc and osmotic water flow across toad bladder6. It has been suggested that cyclic AMP is the more direct mediator of the permeability change and that vasopressin and theophylline exert their effects by increasing the concentration of cyclic AMP in the epithelial cells7. More... »

PAGES

469-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/217469a0

DOI

http://dx.doi.org/10.1038/217469a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026750440

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5641769


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