A reversibly antigen-responsive hydrogel View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-06

AUTHORS

Takashi Miyata, Noriko Asami, Tadashi Uragami

ABSTRACT

Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedicine and the creation of 'intelligent' materials systems, for example as media for drug delivery, separation processes and protein immobilization. Hydrogels have been reported that respond to pH, temperature, electric fields and saccharides. For some biomedical applications it would be very useful to have a material whose swelling response was dictated by a specific protein. Here we report such a material, which swells reversibly in a buffer solution in response to a specific antigen. The hydrogel was prepared by grafting the antigen and corresponding antibody to the polymer network, so that binding between the two introduces crosslinks in the network. Competitive binding of the free antigen triggers a change in gel volume owing to breaking of these non-covalent crosslinks. In addition, we show that the hydrogel displays shape-memory behaviour, and that stepwise changes in antigen concentration can induce pulsatile permeation of a protein through the network. More... »

PAGES

766-769

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/21619

DOI

http://dx.doi.org/10.1038/21619

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035335278

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10391240


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