Oxygen Binding by Haemoglobin J-Cape Town (α2 92 Arg → Gln) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1967-07

AUTHORS

J. G. LINES, ROSALIND MCINTOSH

ABSTRACT

AN abnormal haemoglobin with the electrophoretic mobility of a haemoglobin J has been found in Cape Town, South Africa, and subsequently shown to be α2(92 Arg→Gln)β2 (ref. 1). The oxygen binding characteristics of this new haemoglobin are of particular interest because haemoglobin J-Chesapeake, which has the substitution Arg→Leu in the same position, has been shown to have an abnormally high affinity for oxygen2. Residue 92 of the α chain occupies the position 4 in the non-helical sequence between the helical segments which have been denoted by F and G (ref. 3), and it is in this area that the α and β chains are sliding past each other during oxygenation and deoxygenation of the haemoglobin molecule (personal communication from Perutz). A substitution of glutamine for arginine in this position can therefore be expected to influence the functional properties of the molecule and the haem–haem interaction. More... »

PAGES

297

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

5098

VOLUME

215

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/215297a0

DOI

http://dx.doi.org/10.1038/215297a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050775064


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "LINES", 
        "givenName": "J. G.", 
        "type": "Person"
      }, 
      {
        "familyName": "MCINTOSH", 
        "givenName": "ROSALIND", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/212792a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005113934", 
          "https://doi.org/10.1038/212792a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2795(67)90463-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011271656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2795(67)90463-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011271656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(58)90094-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015782625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(65)80133-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030936782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076657178", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1967-07", 
    "datePublishedReg": "1967-07-01", 
    "description": "AN abnormal haemoglobin with the electrophoretic mobility of a haemoglobin J has been found in Cape Town, South Africa, and subsequently shown to be \u03b12(92 Arg\u2192Gln)\u03b22 (ref. 1). The oxygen binding characteristics of this new haemoglobin are of particular interest because haemoglobin J-Chesapeake, which has the substitution Arg\u2192Leu in the same position, has been shown to have an abnormally high affinity for oxygen2. Residue 92 of the \u03b1 chain occupies the position 4 in the non-helical sequence between the helical segments which have been denoted by F and G (ref. 3), and it is in this area that the \u03b1 and \u03b2 chains are sliding past each other during oxygenation and deoxygenation of the haemoglobin molecule (personal communication from Perutz). A substitution of glutamine for arginine in this position can therefore be expected to influence the functional properties of the molecule and the haem\u2013haem interaction.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1038/215297a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5098", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "215"
      }
    ], 
    "name": "Oxygen Binding by Haemoglobin J-Cape Town (\u03b12 92 Arg \u2192 Gln)", 
    "pagination": "297", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f1df3cc09b194203a81b4153b6a1e327fffea76597b496ff02cfec1492356237"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/215297a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050775064"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/215297a0", 
      "https://app.dimensions.ai/details/publication/pub.1050775064"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/215297a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/215297a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/215297a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/215297a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/215297a0'


 

This table displays all metadata directly associated to this object as RDF triples.

76 TRIPLES      21 PREDICATES      32 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/215297a0 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N3d8c869dfd5547bc9f65155e404538c5
4 schema:citation sg:pub.10.1038/212792a0
5 https://app.dimensions.ai/details/publication/pub.1076657178
6 https://doi.org/10.1016/0003-9861(58)90094-8
7 https://doi.org/10.1016/0005-2795(67)90463-1
8 https://doi.org/10.1016/s0022-2836(65)80133-4
9 schema:datePublished 1967-07
10 schema:datePublishedReg 1967-07-01
11 schema:description AN abnormal haemoglobin with the electrophoretic mobility of a haemoglobin J has been found in Cape Town, South Africa, and subsequently shown to be α2(92 Arg→Gln)β2 (ref. 1). The oxygen binding characteristics of this new haemoglobin are of particular interest because haemoglobin J-Chesapeake, which has the substitution Arg→Leu in the same position, has been shown to have an abnormally high affinity for oxygen2. Residue 92 of the α chain occupies the position 4 in the non-helical sequence between the helical segments which have been denoted by F and G (ref. 3), and it is in this area that the α and β chains are sliding past each other during oxygenation and deoxygenation of the haemoglobin molecule (personal communication from Perutz). A substitution of glutamine for arginine in this position can therefore be expected to influence the functional properties of the molecule and the haem–haem interaction.
12 schema:genre non_research_article
13 schema:inLanguage en
14 schema:isAccessibleForFree false
15 schema:isPartOf Nb5deaa6abc3a415a9358668939017dc9
16 Nca31aeadefad430b99510eeec31c3353
17 sg:journal.1018957
18 schema:name Oxygen Binding by Haemoglobin J-Cape Town (α2 92 Arg → Gln)
19 schema:pagination 297
20 schema:productId N3b704670dd364216ac3dd713c5e53e50
21 N6622614704f8400c8004cb2f07709d85
22 N9e0e607da9dc428e94a8c38aacfc49f4
23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050775064
24 https://doi.org/10.1038/215297a0
25 schema:sdDatePublished 2019-04-10T14:48
26 schema:sdLicense https://scigraph.springernature.com/explorer/license/
27 schema:sdPublisher N7ca00a90454d46cd86f5dec0d242019f
28 schema:url https://www.nature.com/articles/215297a0
29 sgo:license sg:explorer/license/
30 sgo:sdDataset articles
31 rdf:type schema:ScholarlyArticle
32 N3b704670dd364216ac3dd713c5e53e50 schema:name dimensions_id
33 schema:value pub.1050775064
34 rdf:type schema:PropertyValue
35 N3d8c869dfd5547bc9f65155e404538c5 rdf:first N6533128d3ad148429aab49872ee6887a
36 rdf:rest N454b0ef236cc4f839a1772a49f93742b
37 N454b0ef236cc4f839a1772a49f93742b rdf:first Nf696d85f9b6e43469e4a9d8a7877b052
38 rdf:rest rdf:nil
39 N6533128d3ad148429aab49872ee6887a schema:familyName LINES
40 schema:givenName J. G.
41 rdf:type schema:Person
42 N6622614704f8400c8004cb2f07709d85 schema:name doi
43 schema:value 10.1038/215297a0
44 rdf:type schema:PropertyValue
45 N7ca00a90454d46cd86f5dec0d242019f schema:name Springer Nature - SN SciGraph project
46 rdf:type schema:Organization
47 N9e0e607da9dc428e94a8c38aacfc49f4 schema:name readcube_id
48 schema:value f1df3cc09b194203a81b4153b6a1e327fffea76597b496ff02cfec1492356237
49 rdf:type schema:PropertyValue
50 Nb5deaa6abc3a415a9358668939017dc9 schema:issueNumber 5098
51 rdf:type schema:PublicationIssue
52 Nca31aeadefad430b99510eeec31c3353 schema:volumeNumber 215
53 rdf:type schema:PublicationVolume
54 Nf696d85f9b6e43469e4a9d8a7877b052 schema:familyName MCINTOSH
55 schema:givenName ROSALIND
56 rdf:type schema:Person
57 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
58 schema:name Biological Sciences
59 rdf:type schema:DefinedTerm
60 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
61 schema:name Biochemistry and Cell Biology
62 rdf:type schema:DefinedTerm
63 sg:journal.1018957 schema:issn 0090-0028
64 1476-4687
65 schema:name Nature
66 rdf:type schema:Periodical
67 sg:pub.10.1038/212792a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005113934
68 https://doi.org/10.1038/212792a0
69 rdf:type schema:CreativeWork
70 https://app.dimensions.ai/details/publication/pub.1076657178 schema:CreativeWork
71 https://doi.org/10.1016/0003-9861(58)90094-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015782625
72 rdf:type schema:CreativeWork
73 https://doi.org/10.1016/0005-2795(67)90463-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011271656
74 rdf:type schema:CreativeWork
75 https://doi.org/10.1016/s0022-2836(65)80133-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030936782
76 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...