Haemoglobin Genova: β28 (B10) Leucine→Proline View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1967-05

AUTHORS

G. SANSONE, R. W. CARRELL, H. LEHMANN

ABSTRACT

An unstable haemoglobin with the electrophoretic properties of normal adult haemoglobin A has been identified in a Genoese family with severe haemolytic anaemia. It differs from A by the substitution in its β-chain of proline for leucine at position 10 of the B helix. This substitution accounts for the disease in molecular terms because proline would interrupt the helical configuration. More... »

PAGES

877-879

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/214877a0

DOI

http://dx.doi.org/10.1038/214877a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001881084

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6054966


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