Characterization of Antilymphocytic Antibody View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1967-06

AUTHORS

K. JAMES, P. B. MEDAWAR

ABSTRACT

ANTILYMPHOCYTIC serum (ALS) is now well known to have the power of prolonging the life of homografts on the animals into which it is injected1–3. All who have studied ALS agree that a high proportion of its immunosuppressive power resides in the 7S globulin fraction2. The experiments described here represent a formal analysis of the power of different fractions of ALS raised in rabbits and horses to prolong the life of A-strain tail skin homo-grafts on CBA mice. Rabbit antisera against mouse thymocytes were prepared by the method of Levey and Medawar3. The horse antiserum, made by a scaled-up variant of the same technique, was kindly supplied to us by the Wellcome Foundation. The serum fractions were normally reconstituted to the concentrations at which they were originally present in whole serum, and assayed by the subcutaneous injection of 0.5 ml. on the second and again on the fifth days after skin grafting3. More... »

PAGES

1052-1053

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2141052b0

DOI

http://dx.doi.org/10.1038/2141052b0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051884022

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6055408


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