Enhanced Susceptibility of Thymectomized and Irradiated Mice to Infection with Mycobacterium leprae View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1966-08

AUTHORS

R. J. W. REES

ABSTRACT

SINCE 1960 it has been established beyond doubt that a limited infection with the human leprosy bacillus, Mycobacterium leprae, can be produced in the mouse foot-pad1,2. Quantitative analyses have shown that the multiplication of Myco. leprae is limited, is dependent on the size of the inoculum and is confined to the site of inoculation. For example, inocula of 104Myco. leprae yield 106 in 6–8 months, and although smaller inocula may eventually give the same yield, larger ones give no higher yields, and inocula of 106 or more fail to multiply significantly. Once the bacterial population in the foot-pad has reached approximately 106, it remains steady for many months although there is a gradual increase in the proportion of dead bacilli2. An identical type of limited infection has been obtained in the hamster ear and foot-pad3,4. Therefore, although the long-awaited successful transmission of Myco. leprae to animals offers for the first time an opportunity for examining human leprosy experimentally, progress in this field is now being restricted by the limited nature of the infection. One of the most likely limiting factors is an immunological one resulting from the infection. This suggestion is strengthened by the observations of Shepard5 that prior vaccination with BCG given either locally in the foot-pad or at other sites in the body, more or less completely inhibits the multiplication of Myco. leprae inoculated later into the mouse foot-pad. Cortisone6 and suramin7,8, compounds which have been shown to enhance significantly infection with other species of mycobacteria, have no effect on infections with Myco. leprae in the mouse foot-pad2,9. On the assumption that the limiting factor has an immunological basis, an attempt to enhance the infection by prior exposure of the mice to thymectomy plus total-body irradiation was tried because of the known powerful immunological depressive effect of these combined procedures in the homograft reaction and antibody production. More... »

PAGES

657-658

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/211657a0

DOI

http://dx.doi.org/10.1038/211657a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041979842

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5338822


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