A New Type of Cytotoxic Immunosuppressive Agent: 3-Acetyl-5-(4-fluorobenzylidene)4-hydroxy-2-oxo-2:5-dihydrothiophen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1966-05

AUTHORS

T. J. FRANKLIN, B. B. NEWBOULD, D. M. O'MANT, A. I. SCOTT, G. J. STACEY, G. E. DAVIES

ABSTRACT

DURING the past 3 years we have been investigating the biological properties of a series of thiophens of tho following general formula (I): in which R is an alkyl or alkoxy group and the substituent X is an electron-withdrawing group such as halogen or nitro. These investigations resulted from the observation that the compound I.C.I. 45,514 (I, R = ethoxy, X = H) prevented the development of secondary inflamed lesions in rats injected into the foot-pad with a fine suspension of dead tubercle bacilli in liquid paraffin. The use of this syndrome for evaluating chemotherapeutic agents has already been described1,2. More... »

PAGES

638-639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/210638a0

DOI

http://dx.doi.org/10.1038/210638a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029791612

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5964708


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