Amino-acid Substitutions in Haemoglobins and the Mutation Process View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1966-04

AUTHORS

F. VOGEL, G. RÖHRBO

ABSTRACT

VARIOUS genetically determined human and animal haemoglobins differ in the amino-acid sequences of their polypeptide chains1,3,6. On the basis of the ribonucleic acid triplets published recently4,5 all abnormal human haemoglobins which are due to single amino-acid substitutions can be explained by single base pair changes in the deoxyribonucleic acid. Comparing the normal human β- and δ-chains we found that only the exchange of threonine to glutamine in position 87 (1 of 10) cannot be interpreted by a single point mutation. More... »

PAGES

116

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/210116a0

DOI

http://dx.doi.org/10.1038/210116a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021236739

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6006133


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