Ontology type: schema:ScholarlyArticle
1965-07
AUTHORSJ. J. T. OWEN, M. A. S. MOORE, G. A. HARRISON
ABSTRACTTHE production of splenomegaly and other lesions by the injection of adult avian blood into the chick embryo is due to an immunological reaction between donor blood cells and host embryo tissues1,2. Biggs and Payne3 have shown that the reaction is accompanied by proliferation of donor cells within the host spleen. They were able to distinguish donor (male) cells from host (female) cells by identifying the respective sex chromosome complements. Cells of male sex have a ZZ chromosome constitution, whereas female cells have a single Z chromosome4,5. The Z chromosome is the only large mediocentric element in avian cells and is therefore readily identified in good chromosome preparations. Thus Biggs and Payne demonstrated proliferation of donor (ZZ) cells in the spleens of female embryos injected with cockerel blood. However, they found that the majority of dividing cells were of host type and they suggested that increased proliferation of host as well as donor elements must be responsible for splenic enlargement. Their investigation was limited to an analysis of 170 cells sampled from 9 embryo spleens removed 4 days after injection. Despite the obvious desirability of obtaining further information regarding the relative roles of donor and host proliferation in producing splenomegaly, no subsequent work has been reported. It would appear that technical difficulties involved in the preparation of clear metaphase figures from avian tissues have prevented further application of the method to the identification of cells. More... »
PAGES313-315
http://scigraph.springernature.com/pub.10.1038/207313b0
DOIhttp://dx.doi.org/10.1038/207313b0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1020630206
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/5886238
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Paediatrics and Reproductive Medicine",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Weight",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chick Embryo",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosomes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "In Vitro Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Organ Size",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spleen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation Immunology",
"type": "DefinedTerm"
}
],
"author": [
{
"familyName": "OWEN",
"givenName": "J. J. T.",
"id": "sg:person.066106211.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066106211.66"
],
"type": "Person"
},
{
"familyName": "MOORE",
"givenName": "M. A. S.",
"type": "Person"
},
{
"familyName": "HARRISON",
"givenName": "G. A.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/ar.1090700204",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016600627"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-196501000-00006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031300905"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-196501000-00006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031300905"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/1841594a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031702675",
"https://doi.org/10.1038/1841594a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10520296209114560",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039000016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10520296309061189",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049528241"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-196301020-00007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051199545"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-196301020-00007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051199545"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1508/cytologia.13.270",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051976737"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.137.3534.984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062478107"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075753282",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076113709",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076163196",
"type": "CreativeWork"
}
],
"datePublished": "1965-07",
"datePublishedReg": "1965-07-01",
"description": "THE production of splenomegaly and other lesions by the injection of adult avian blood into the chick embryo is due to an immunological reaction between donor blood cells and host embryo tissues1,2. Biggs and Payne3 have shown that the reaction is accompanied by proliferation of donor cells within the host spleen. They were able to distinguish donor (male) cells from host (female) cells by identifying the respective sex chromosome complements. Cells of male sex have a ZZ chromosome constitution, whereas female cells have a single Z chromosome4,5. The Z chromosome is the only large mediocentric element in avian cells and is therefore readily identified in good chromosome preparations. Thus Biggs and Payne demonstrated proliferation of donor (ZZ) cells in the spleens of female embryos injected with cockerel blood. However, they found that the majority of dividing cells were of host type and they suggested that increased proliferation of host as well as donor elements must be responsible for splenic enlargement. Their investigation was limited to an analysis of 170 cells sampled from 9 embryo spleens removed 4 days after injection. Despite the obvious desirability of obtaining further information regarding the relative roles of donor and host proliferation in producing splenomegaly, no subsequent work has been reported. It would appear that technical difficulties involved in the preparation of clear metaphase figures from avian tissues have prevented further application of the method to the identification of cells.",
"genre": "research_article",
"id": "sg:pub.10.1038/207313b0",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "4994",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "207"
}
],
"name": "Chromosome Marker Studies in the Graft-versus-Host Reaction in the Chick Embryo",
"pagination": "313-315",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"624c90924c1f2c5e2df5d34d1e8f454f9f576c923e9e3750f41ed80070203187"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"5886238"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/207313b0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1020630206"
]
}
],
"sameAs": [
"https://doi.org/10.1038/207313b0",
"https://app.dimensions.ai/details/publication/pub.1020630206"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T16:28",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/207313b0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/207313b0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/207313b0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/207313b0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/207313b0'
This table displays all metadata directly associated to this object as RDF triples.
150 TRIPLES
21 PREDICATES
51 URIs
32 LITERALS
20 BLANK NODES