Specific Technique for the Isolation of Human α2-Macroglobulin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1965-03

AUTHORS

M. STEINBUCH, M. QUENTIN, L. PEJAUDIER

ABSTRACT

NORMAL human serum contains two kinds of macroglobulin, the γ1M (or β2M)-group and α2-macroglobulin; the latter was first isolated and described by Schultze and co-workers1. The macroglobulin isolated by Brown et al. from Cohn's Fraction III° seems to be the same protein2. Although α2-macroglobulin corresponds to about 3 per cent of total serum protein, its biological significance is still unknown. This may be a sufficient explanation for the rather scarce literature concerning it. However, it seems to us that the main reason might be the difficulty of obtaining this protein in a pure state and in sufficient quantity. This involves a complete fractionation scheme1,2, or the use of small-scale techniques involving ultracentrifugation or preparative electrophoresis3–5. A specific and simple isolation technique is still lacking. More... »

PAGES

1227

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

4977

VOLUME

205

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2051227a0

DOI

http://dx.doi.org/10.1038/2051227a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006403781


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