An Unidentified Virus which causes the Rapid Production of Tumours in Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1964-12

AUTHORS

J. J. HARVEY

ABSTRACT

IN the course of routine passage of Moloney's leukæmogenic virus (MLV) plasma was collected from a leukæmic rat (Chester Beatty Institute outbred albino strain) which had been inoculated with MLV-containing mouse plasma when new-born. After storage at −70°C for three months the rat plasma was diluted 1 in 30 with Hanks's saline and passed through a ‘Selas 02’ filter, tested and found impervious to Esch. coli. The filtrate was injected into 15 new-born BALB/c mice, as a test of potency. Only 6 survived to weaning. On the 32nd day 5 had tumours at or near the injection site, and all had grossly enlarged spleens. Usually mice inoculated with MLV remain symptomless until they show the characteristic signs of leukæmia after 8 weeks. More... »

PAGES

1104-1105

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2041104b0

DOI

http://dx.doi.org/10.1038/2041104b0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026992487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14243400


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