Differentiation and reversal of malignant changes in colon cancer through PPARγ View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-09

AUTHORS

Pasha Sarraf, Elisabetta Mueller, Daniel Jones, Frederick J. King, Daniel J. DeAngelo, Jeffrey B. Partridge, Sylvia A. Holden, Lan Bo Chen, Samuel Singer, Christopher Fletcher, Bruce M. Spiegelman

ABSTRACT

PPARγ is a nuclear receptor that has a dominant regulatory role in differentiation of cells of the adipose lineage, and has recently been shown to be expressed in the colon. We show here that PPARγ is expressed at high levels in both well- and poorly-differentiated adenocarcinomas, in normal colonic mucosa and in human colon cancer cell lines. Ligand activation of this receptor in colon cancer cells causes a considerable reduction in linear and clonogenic growth, increased expression of carcinoembryonic antigen and the reversal of many gene expression events specifically associated with colon cancer. Transplantable tumors derived from human colon cancer cells show a significant reduction of growth when mice are treated with troglitazone, a PPARγ ligand. These results indicate that the growth and differentiation of colon cancer cells can be modulated through PPARγ. More... »

PAGES

1046-1052

Journal

TITLE

Nature Medicine

ISSUE

9

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2030

DOI

http://dx.doi.org/10.1038/2030

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007380590

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9734398


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