Co-transduction by a Staphylococcal Phage of the Genes Responsible for Penicillinase Synthesis and Resistance to Mercury Salts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1964-06

AUTHORS

M. H. RICHMOND, MADELEINE JOHN

ABSTRACT

STRAINS of Staphylococcus aureus endemic in hospitals are usually resistant to several antibiotics, including penicillin, and to mercury salts1. A recent survey2 showed a correlation between multiple resistance to antibiotics and the ability to produce large amounts of penicillinase under appropriate conditions. The highest correlation, however, was between high penicillinase activity and mercury resistance. It has been known for some time that penicillinase-producing strains of S. aureus readily revert to the penicillin-sensitive state3. Novick4 has shown that this process can occur as frequently as once every 103 generations, and that the step involves loss both of the gene responsible for synthesis of the penicillinase molecule itself and the genes conferring inducible properties on penicillinase synthesis. More... »

PAGES

1360-1361

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2021360a0

DOI

http://dx.doi.org/10.1038/2021360a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039355438

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14210993


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