Inhibition of Protein Synthesis in vitro by Cycloheximide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1963-11

AUTHORS

MALCOLM R. SIEGEL, HUGH D. SISLER

ABSTRACT

CYCLOHEXIMIDE (‘Actidione’), an antifungal antibiotic, isolated from Streptomyces griseus, was reported by Kerridge1 to inhibit protein synthesis in Saccharomyces carlsbergenesis. These observations have been substantiated by other workers2,4. Recent investigations indicate that the changes produced by cycloheximide in intermediate metabolism, such as amino-acid, organic acid, adenosine triphosphate (ATP), and other nucleotide production, is not responsible for the inhibition of protein synthesis3,4. The data presented here will show that incorporation of leucine labelled with carbon-14 into protein in a cell-free system from Saccharomyces pastorianus is inhibited by low concentrations of cycloheximide. More... »

PAGES

675-676

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/200675a0

DOI

http://dx.doi.org/10.1038/200675a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031116090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14109947


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