1963-07
AUTHORSRONALD G. DAVIDSON, SAUL W. BRUSILOW, HAROLD M. NITOWSKY
ABSTRACTONE of the most useful tissues available to the human geneticist for cell culture is skin. It is plentiful, easy to grow, remains diploid for several months, and can be frozen, stored for probably years, then thawed and re-cultured1. What is needed for large-scale family or population studies is a simple, rapid, relatively painless procedure for obtaining suitable skin biopsies. Just such a procedure, using an electric rotary punch, is described in the literature by Urbach and Shelley2; but few investigators outside the field of dermatology seem to be aware of the technique. We have had such good results with an adaptation of the punch drill that we call attention to it in this communication and present our results to date. The procedure is as rapid and simple as a veni-puncture, and certainly no more painful. No anaesthesia or suture is required, and the biopsy can be performed in the clinic, the office, or the patient's home. More... »
PAGES296-297
http://scigraph.springernature.com/pub.10.1038/199296b0
DOIhttp://dx.doi.org/10.1038/199296b0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1022602889
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14076703
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Culture Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Equipment and Supplies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetics, Medical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Research",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Skin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Culture Techniques",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Pediatrics, The Johns Hopkins University School of Medicine",
"id": "http://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pediatrics, The Johns Hopkins University School of Medicine"
],
"type": "Organization"
},
"familyName": "DAVIDSON",
"givenName": "RONALD G.",
"id": "sg:person.071354243.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071354243.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Harriet Lane Home, The Johns Hopkins Hospital",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Harriet Lane Home, The Johns Hopkins Hospital"
],
"type": "Organization"
},
"familyName": "BRUSILOW",
"givenName": "SAUL W.",
"id": "sg:person.0670447233.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670447233.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatrics, Sinai Hospital, Baltimore, Maryland",
"id": "http://www.grid.ac/institutes/grid.415936.c",
"name": [
"Department of Pediatrics, Sinai Hospital, Baltimore, Maryland"
],
"type": "Organization"
},
"familyName": "NITOWSKY",
"givenName": "HAROLD M.",
"id": "sg:person.066061043.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066061043.06"
],
"type": "Person"
}
],
"datePublished": "1963-07",
"datePublishedReg": "1963-07-01",
"description": "ONE of the most useful tissues available to the human geneticist for cell culture is skin. It is plentiful, easy to grow, remains diploid for several months, and can be frozen, stored for probably years, then thawed and re-cultured1. What is needed for large-scale family or population studies is a simple, rapid, relatively painless procedure for obtaining suitable skin biopsies. Just such a procedure, using an electric rotary punch, is described in the literature by Urbach and Shelley2; but few investigators outside the field of dermatology seem to be aware of the technique. We have had such good results with an adaptation of the punch drill that we call attention to it in this communication and present our results to date. The procedure is as rapid and simple as a veni-puncture, and certainly no more painful. No anaesthesia or suture is required, and the biopsy can be performed in the clinic, the office, or the patient's home.",
"genre": "article",
"id": "sg:pub.10.1038/199296b0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4890",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "199"
}
],
"keywords": [
"large-scale family",
"culture",
"home",
"communication",
"literature",
"attention",
"adaptation",
"family",
"office",
"skin biopsies",
"field",
"field of dermatology",
"punch",
"date",
"study",
"drill",
"painless procedure",
"years",
"patient's home",
"cell cultures",
"biopsy",
"population studies",
"useful tissue",
"geneticists",
"anesthesia",
"human geneticists",
"clinic",
"months",
"Urbach",
"dermatology",
"such good results",
"results",
"skin",
"suture",
"procedure",
"tissue",
"investigators",
"better results",
"technique",
"diploid"
],
"name": "Skin Biopsy for Cell Culture",
"pagination": "296-297",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1022602889"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/199296b0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"14076703"
]
}
],
"sameAs": [
"https://doi.org/10.1038/199296b0",
"https://app.dimensions.ai/details/publication/pub.1022602889"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T21:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_103.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/199296b0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/199296b0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/199296b0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/199296b0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/199296b0'
This table displays all metadata directly associated to this object as RDF triples.
149 TRIPLES
20 PREDICATES
73 URIs
65 LITERALS
14 BLANK NODES