Reduced Antibody Response in Thymectomized Rabbits View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1962-07

AUTHORS

OLGA K. ARCHER, JAMES C. PIERCE, BEN W. PAPERMASTER, ROBERT A. GOOD

ABSTRACT

DESPITE considerable experimental work, the function of the thymus has not yet been clearly delineated. Although it is an organ rich in lymphoid cells, it differs from other lymphoid organs in its failure to produce significant amounts of antibody after antigenic stimulation1–3 and in its embryonic origin from the endoderm of the third pharyngeal pouch. The thymus is largest relative to body-weight during the period of immunological deficiency early in life and it becomes progressively smaller after the immune responses are fully developed4, a growth pattern which suggests its relation to the development of immunological mechanisms. The occurrence in the same patient of the two rare conditions, namely, benign thymoma and acquired agamma-globulinæmia5–7, suggested a relationship of the thymus to immunological processes. Thymectomy in adult or even in young rabbits6,8,9 had no effect on their antibody response, but subtotal thymectomy performed on young guinea pigs caused reduced antibody formation in some of the experimental groups10. More... »

PAGES

191-193

References to SciGraph publications

  • 1956-09. The Thymic Origin of the Plasma Lymphocytosis Stimulating Factor in BRITISH JOURNAL OF CANCER
  • 1959-12. The role of the lymphoid organs in antibody production in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • 1960-03. Runt Disease and Tolerance in Rabbits in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/195191a0

    DOI

    http://dx.doi.org/10.1038/195191a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017717349

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/13862076


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