Isoxazolyl Penicillins and Penicillinase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1962-09

AUTHORS

J. T. SMITH, J. M. T. HAMILTON-MILLER, R. KNOX

ABSTRACT

THE isoxazolyl series of penicillinase-resistant penicillins has been described by Doyle et al.1. Many members of this series are acid-stable, and considerably more active against staphylococci than methi-cillin. Three members of this series (BRL.1400 5-methyl-3-phenyl-4-isoxazolylpenicillin, BRL. 1577 5-methyl-3-p-chlorphenyl-4-isoxazolylpenicillin and BRL.1621 5-methyl-3-o-chlorphenyl-4-isoxazolylpenicillin) have been investigated for antibacterial activity and for stability to, induction of, affinity for, and inhibitory action on, the penicillinases of Staph. aureus and B. cereus. More... »

PAGES

1300-1301

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/1951300a0

DOI

http://dx.doi.org/10.1038/1951300a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049584104

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13989490


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