Large Lymphocytes and the Simonsen Phenomenon View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1961-08

AUTHORS

A. SZENBERG, N. L. WAER

ABSTRACT

WHEN blood cells from an adult fowl are inoculated on the chorioallantoic membrane of the 12-day-chick embryo, easily visible opaque foci are produced1,2. This reaction is thought to be similar to the induction of splenomegaly following intravenous inoculation of adult fowl blood into the chick embryo3. The cells in blood responsible for this latter action have been found to be the lymphocytes4. Fowls are typical of the avian family in having a high proportion of circulating large lymphocytes, usually about 10 per cent, and, as autoradiographic investigations5,6 have shown that large lymphocytes and not small can synthesize deoxyribonucleic acid and proliferate, an investigation was made to determine the type of lymphocyte responsible for the induction of lesions on the chorioallantoic membrane. Blood from a group of 25 random fowls was titrated on the chorioallantoic membrane, the number of small and of large lymphocytes in the inoculated blood having been determined. A highly significant correlation (0.1 per cent in Student's t test) of the number of large lymphocytes in the inoculum with the median focal count was demonstrated. The correlation of small lymphocytes with the focal count was not significant (> 5 per cent). In repeated titrations of individual fowls, the focal count was also shown to depend on the number of large lymphocytes in the inoculum and to be quite independent of the number of small lymphocytes. More... »

PAGES

920

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/191920a0

DOI

http://dx.doi.org/10.1038/191920a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015940377

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13774548


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiemetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "SZENBERG", 
        "givenName": "A.", 
        "id": "sg:person.053173326.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053173326.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "WAER", 
        "givenName": "N. L.", 
        "id": "sg:person.011122363377.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122363377.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/path.1700810117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1700810117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/185327a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044738900", 
          "https://doi.org/10.1038/185327a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075753282", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076040494", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076053313", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1961-08", 
    "datePublishedReg": "1961-08-01", 
    "description": "WHEN blood cells from an adult fowl are inoculated on the chorioallantoic membrane of the 12-day-chick embryo, easily visible opaque foci are produced1,2. This reaction is thought to be similar to the induction of splenomegaly following intravenous inoculation of adult fowl blood into the chick embryo3. The cells in blood responsible for this latter action have been found to be the lymphocytes4. Fowls are typical of the avian family in having a high proportion of circulating large lymphocytes, usually about 10 per cent, and, as autoradiographic investigations5,6 have shown that large lymphocytes and not small can synthesize deoxyribonucleic acid and proliferate, an investigation was made to determine the type of lymphocyte responsible for the induction of lesions on the chorioallantoic membrane. Blood from a group of 25 random fowls was titrated on the chorioallantoic membrane, the number of small and of large lymphocytes in the inoculated blood having been determined. A highly significant correlation (0.1 per cent in Student's t test) of the number of large lymphocytes in the inoculum with the median focal count was demonstrated. The correlation of small lymphocytes with the focal count was not significant (> 5 per cent). In repeated titrations of individual fowls, the focal count was also shown to depend on the number of large lymphocytes in the inoculum and to be quite independent of the number of small lymphocytes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/191920a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4791", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "191"
      }
    ], 
    "name": "Large Lymphocytes and the Simonsen Phenomenon", 
    "pagination": "920", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4bf429a1553bce0593eca3cd9402608115b5d9eb57e90af91b3fa5326905325a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "13774548"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/191920a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015940377"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/191920a0", 
      "https://app.dimensions.ai/details/publication/pub.1015940377"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/191920a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/191920a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/191920a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/191920a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/191920a0'


 

This table displays all metadata directly associated to this object as RDF triples.

92 TRIPLES      21 PREDICATES      36 URIs      23 LITERALS      11 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/191920a0 schema:about N337904f1452041909ffcfcd668e6521f
2 Nbeaec81ab59a474dafb7939e7ba3ec85
3 anzsrc-for:11
4 anzsrc-for:1107
5 schema:author N312d10782b9b47778e4e06e55e3317bb
6 schema:citation sg:pub.10.1038/185327a0
7 https://app.dimensions.ai/details/publication/pub.1075753282
8 https://app.dimensions.ai/details/publication/pub.1076040494
9 https://app.dimensions.ai/details/publication/pub.1076053313
10 https://doi.org/10.1002/path.1700810117
11 schema:datePublished 1961-08
12 schema:datePublishedReg 1961-08-01
13 schema:description WHEN blood cells from an adult fowl are inoculated on the chorioallantoic membrane of the 12-day-chick embryo, easily visible opaque foci are produced1,2. This reaction is thought to be similar to the induction of splenomegaly following intravenous inoculation of adult fowl blood into the chick embryo3. The cells in blood responsible for this latter action have been found to be the lymphocytes4. Fowls are typical of the avian family in having a high proportion of circulating large lymphocytes, usually about 10 per cent, and, as autoradiographic investigations5,6 have shown that large lymphocytes and not small can synthesize deoxyribonucleic acid and proliferate, an investigation was made to determine the type of lymphocyte responsible for the induction of lesions on the chorioallantoic membrane. Blood from a group of 25 random fowls was titrated on the chorioallantoic membrane, the number of small and of large lymphocytes in the inoculated blood having been determined. A highly significant correlation (0.1 per cent in Student's t test) of the number of large lymphocytes in the inoculum with the median focal count was demonstrated. The correlation of small lymphocytes with the focal count was not significant (> 5 per cent). In repeated titrations of individual fowls, the focal count was also shown to depend on the number of large lymphocytes in the inoculum and to be quite independent of the number of small lymphocytes.
14 schema:genre research_article
15 schema:inLanguage en
16 schema:isAccessibleForFree false
17 schema:isPartOf N1460ba2273124342806f9e96771f06cb
18 Nea341d647df448e7b7f2cad9a2853c3e
19 sg:journal.1018957
20 schema:name Large Lymphocytes and the Simonsen Phenomenon
21 schema:pagination 920
22 schema:productId N287c0c16098d49248ff0189522e9524d
23 N896231fb22b0457eb4bd98f266b06899
24 N913f0910bcaf41c5beddf20e59a773d1
25 Nb70c20927fd84c3792e5a56f28a573e9
26 Ncd76cf844c054f8186dff9940e2bc708
27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015940377
28 https://doi.org/10.1038/191920a0
29 schema:sdDatePublished 2019-04-10T22:19
30 schema:sdLicense https://scigraph.springernature.com/explorer/license/
31 schema:sdPublisher Nd00d8d20779842648380bcb05862993b
32 schema:url https://www.nature.com/articles/191920a0
33 sgo:license sg:explorer/license/
34 sgo:sdDataset articles
35 rdf:type schema:ScholarlyArticle
36 N1460ba2273124342806f9e96771f06cb schema:volumeNumber 191
37 rdf:type schema:PublicationVolume
38 N287c0c16098d49248ff0189522e9524d schema:name doi
39 schema:value 10.1038/191920a0
40 rdf:type schema:PropertyValue
41 N312d10782b9b47778e4e06e55e3317bb rdf:first sg:person.053173326.25
42 rdf:rest N6d73f2edb4a44db39f926f72136b906f
43 N337904f1452041909ffcfcd668e6521f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
44 schema:name Antiemetics
45 rdf:type schema:DefinedTerm
46 N6d73f2edb4a44db39f926f72136b906f rdf:first sg:person.011122363377.06
47 rdf:rest rdf:nil
48 N896231fb22b0457eb4bd98f266b06899 schema:name dimensions_id
49 schema:value pub.1015940377
50 rdf:type schema:PropertyValue
51 N913f0910bcaf41c5beddf20e59a773d1 schema:name readcube_id
52 schema:value 4bf429a1553bce0593eca3cd9402608115b5d9eb57e90af91b3fa5326905325a
53 rdf:type schema:PropertyValue
54 Nb70c20927fd84c3792e5a56f28a573e9 schema:name nlm_unique_id
55 schema:value 0410462
56 rdf:type schema:PropertyValue
57 Nbeaec81ab59a474dafb7939e7ba3ec85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Lymphocytes
59 rdf:type schema:DefinedTerm
60 Ncd76cf844c054f8186dff9940e2bc708 schema:name pubmed_id
61 schema:value 13774548
62 rdf:type schema:PropertyValue
63 Nd00d8d20779842648380bcb05862993b schema:name Springer Nature - SN SciGraph project
64 rdf:type schema:Organization
65 Nea341d647df448e7b7f2cad9a2853c3e schema:issueNumber 4791
66 rdf:type schema:PublicationIssue
67 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
68 schema:name Medical and Health Sciences
69 rdf:type schema:DefinedTerm
70 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
71 schema:name Immunology
72 rdf:type schema:DefinedTerm
73 sg:journal.1018957 schema:issn 0090-0028
74 1476-4687
75 schema:name Nature
76 rdf:type schema:Periodical
77 sg:person.011122363377.06 schema:familyName WAER
78 schema:givenName N. L.
79 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122363377.06
80 rdf:type schema:Person
81 sg:person.053173326.25 schema:familyName SZENBERG
82 schema:givenName A.
83 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053173326.25
84 rdf:type schema:Person
85 sg:pub.10.1038/185327a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044738900
86 https://doi.org/10.1038/185327a0
87 rdf:type schema:CreativeWork
88 https://app.dimensions.ai/details/publication/pub.1075753282 schema:CreativeWork
89 https://app.dimensions.ai/details/publication/pub.1076040494 schema:CreativeWork
90 https://app.dimensions.ai/details/publication/pub.1076053313 schema:CreativeWork
91 https://doi.org/10.1002/path.1700810117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034018644
92 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...