Molecular basis of triclosan activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-04

AUTHORS

Colin W. Levy, Anna Roujeinikova, Svetlana Sedelnikova, Patrick J. Baker, Antoine R. Stuitje, Antoni R. Slabas, David W. Rice, John B. Rafferty

ABSTRACT

Triclosan (5-chloro-2-(2,4-dichlorophenoxy) phenol) has been used for more than 30 years as a general antibacterial and antifungal agent, and is found in formulations as diverse as toothpastes, cosmetics, antiseptic soaps, carpets, plastic kitchenware and toys. It has recently been suggested that triclosan blocks lipid biosynthesis by specifically inhibiting the enzyme enoyl-acyl carrier protein reductase (ENR)1. We have carried out a structural analysis and inhibition experiments on a complex of ENR from the bacterium Escherichia coli with triclosan and NAD+. We find that triclosan acts as a site-directed, very potent inhibitor of the enzyme by mimicking its natural substrate. More... »

PAGES

383-384

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6726

VOLUME

398

Clinical Trials linked to this publication

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/18803

DOI

http://dx.doi.org/10.1038/18803

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031694405

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10201369


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