Activation of a Permeability Factor in Plasma by Contact with Glass View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1958-03

AUTHORS

J. MARGOLIS

ABSTRACT

IT has been shown previously that contact of blood plasma with glass and with certain other surfaces leads to the formation of an unstable substance which accelerates coagulation1. This reaction was found to be similar to the production of a uterus-stimulating and pain-producing substance by glass contact2. Subsequent work showed that both these changes are induced by a common initial reaction in which an inactive precursor is converted into an active agent referred to as the ‘contact factor’3. The purpose of the present communication is to demonstrate that yet another biological activity is induced in cell-free plasma or serum by contact with glass. The investigation was suggested by the work of Miles and Wilhelm, who found that a substance which increases capillary permeability (permeability factor) is formed when plasma or serum is diluted with physiological saline4. More... »

PAGES

635-636

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/181635a0

DOI

http://dx.doi.org/10.1038/181635a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002078270

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13517252


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