Excretion of Yttrium and Lanthanum Chelates of Cyclohexane 1,2-Trans Diamine Tetraacetic Acid and Diethylenetriamine Pentaacetic Acid in Man View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1957-11

AUTHORS

HARRY KROLL, SAMUEL KORMAN, ELSIE SIEGEL, HIRAM E. HART, BETTY ROSOFF, HERTA SPENCER, DANIEL LASZLO

ABSTRACT

THE removal of stable or radioactive toxic elements from the human body is of considerable interest1. The modification of tissue distribution and excretion of metal ions by chelating agents has been studied in man and animals in several laboratories2. Although ethylenediamine tetraacetic acid has been the most effective chelating agent thus far studied, it has the disadvantage that relatively large doses are required in order to effect a significant removal of heavy metal ions, particularly radioactive rare earths. Therefore metal chelates having stability constants higher than the corresponding metal chelates of ethylenediamine tetraacetic acid were investigated for their effectiveness in removal of rare earth elements. More... »

PAGES

919-920

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/180919b0

DOI

http://dx.doi.org/10.1038/180919b0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016429111

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13483559


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0302", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Inorganic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chelating Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclohexanes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lanthanum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pentetic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Yttrium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "KROLL", 
        "givenName": "HARRY", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "KORMAN", 
        "givenName": "SAMUEL", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "SIEGEL", 
        "givenName": "ELSIE", 
        "id": "sg:person.053403431.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053403431.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "HART", 
        "givenName": "HIRAM E.", 
        "id": "sg:person.0110331066.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0110331066.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "ROSOFF", 
        "givenName": "BETTY", 
        "id": "sg:person.063105631.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063105631.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "SPENCER", 
        "givenName": "HERTA", 
        "id": "sg:person.067646242.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067646242.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Division of Neoplastic Diseases, Montefiore Hospital, 67, New York"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LASZLO", 
        "givenName": "DANIEL", 
        "id": "sg:person.061542320.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.061542320.63"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1957-11", 
    "datePublishedReg": "1957-11-01", 
    "description": "THE removal of stable or radioactive toxic elements from the human body is of considerable interest1. The modification of tissue distribution and excretion of metal ions by chelating agents has been studied in man and animals in several laboratories2. Although ethylenediamine tetraacetic acid has been the most effective chelating agent thus far studied, it has the disadvantage that relatively large doses are required in order to effect a significant removal of heavy metal ions, particularly radioactive rare earths. Therefore metal chelates having stability constants higher than the corresponding metal chelates of ethylenediamine tetraacetic acid were investigated for their effectiveness in removal of rare earth elements.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/180919b0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4592", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "180"
      }
    ], 
    "keywords": [
      "toxic elements", 
      "metal ions", 
      "ions", 
      "ethylenediamine tetraacetic acid", 
      "tetraacetic acid", 
      "effective chelating agent", 
      "chelating agent", 
      "significant removal", 
      "heavy metal ions", 
      "rare earth", 
      "metal chelates", 
      "chelates", 
      "stability constants", 
      "corresponding metal chelates", 
      "rare earth elements", 
      "diamine tetraacetic acid", 
      "removal", 
      "human body", 
      "considerable interest1", 
      "interest1", 
      "modification", 
      "agents", 
      "acid", 
      "constants", 
      "earth elements", 
      "yttrium", 
      "cyclohexane", 
      "diethylenetriamine pentaacetic acid", 
      "pentaacetic acid", 
      "elements", 
      "body", 
      "tissue distribution", 
      "distribution", 
      "excretion", 
      "men", 
      "animals", 
      "disadvantages", 
      "large doses", 
      "doses", 
      "order", 
      "Earth", 
      "effectiveness", 
      "radioactive toxic elements", 
      "laboratories2", 
      "radioactive rare earths", 
      "Excretion of Yttrium", 
      "Lanthanum Chelates"
    ], 
    "name": "Excretion of Yttrium and Lanthanum Chelates of Cyclohexane 1,2-Trans Diamine Tetraacetic Acid and Diethylenetriamine Pentaacetic Acid in Man", 
    "pagination": "919-920", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016429111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/180919b0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "13483559"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/180919b0", 
      "https://app.dimensions.ai/details/publication/pub.1016429111"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_69.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/180919b0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/180919b0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/180919b0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/180919b0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/180919b0'


 

This table displays all metadata directly associated to this object as RDF triples.

180 TRIPLES      20 PREDICATES      81 URIs      73 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/180919b0 schema:about N0e9b7d09d2984475b45119941c6c6157
2 N104e60c314f84e9db9cecebe9fe44820
3 N16ec20d548634fffa0bd9224930c3dd2
4 N332271bf8944464aa965da2e18ae3bfa
5 N94a2a1a6f1e14a2f9020cb9c955d5621
6 Nad8b58c057434a59b312ff78105f3f7e
7 Ndf50c0722cb541d0836eb3c9f1ef5b3c
8 Ne836c0cb64324652b17a48d1d0176084
9 anzsrc-for:03
10 anzsrc-for:0302
11 schema:author Nfe74d8b4b8de43dfa58a50c80a6de002
12 schema:datePublished 1957-11
13 schema:datePublishedReg 1957-11-01
14 schema:description THE removal of stable or radioactive toxic elements from the human body is of considerable interest1. The modification of tissue distribution and excretion of metal ions by chelating agents has been studied in man and animals in several laboratories2. Although ethylenediamine tetraacetic acid has been the most effective chelating agent thus far studied, it has the disadvantage that relatively large doses are required in order to effect a significant removal of heavy metal ions, particularly radioactive rare earths. Therefore metal chelates having stability constants higher than the corresponding metal chelates of ethylenediamine tetraacetic acid were investigated for their effectiveness in removal of rare earth elements.
15 schema:genre article
16 schema:isAccessibleForFree false
17 schema:isPartOf N8da0f5c8b5a24f8b922bf78faf51d4d6
18 Nae4ef7deefed45a8a726fd40e11b160a
19 sg:journal.1018957
20 schema:keywords Earth
21 Excretion of Yttrium
22 Lanthanum Chelates
23 acid
24 agents
25 animals
26 body
27 chelates
28 chelating agent
29 considerable interest1
30 constants
31 corresponding metal chelates
32 cyclohexane
33 diamine tetraacetic acid
34 diethylenetriamine pentaacetic acid
35 disadvantages
36 distribution
37 doses
38 earth elements
39 effective chelating agent
40 effectiveness
41 elements
42 ethylenediamine tetraacetic acid
43 excretion
44 heavy metal ions
45 human body
46 interest1
47 ions
48 laboratories2
49 large doses
50 men
51 metal chelates
52 metal ions
53 modification
54 order
55 pentaacetic acid
56 radioactive rare earths
57 radioactive toxic elements
58 rare earth
59 rare earth elements
60 removal
61 significant removal
62 stability constants
63 tetraacetic acid
64 tissue distribution
65 toxic elements
66 yttrium
67 schema:name Excretion of Yttrium and Lanthanum Chelates of Cyclohexane 1,2-Trans Diamine Tetraacetic Acid and Diethylenetriamine Pentaacetic Acid in Man
68 schema:pagination 919-920
69 schema:productId N240e94e6d0154d4d91ba7e41fab01257
70 N6a931d973311482793a1d8c0ce8fa422
71 N8e4dd14441584075b405432bc3af9a24
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016429111
73 https://doi.org/10.1038/180919b0
74 schema:sdDatePublished 2021-12-01T19:35
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Nd8b1107273ab4a83be316eac98a1ba07
77 schema:url https://doi.org/10.1038/180919b0
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N08e3d1df66e84fca9da445b2cf87632f rdf:first sg:person.063105631.72
82 rdf:rest N340e8ed9de4a4ce6a481cf4e757329be
83 N0e9b7d09d2984475b45119941c6c6157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Cyclohexanes
85 rdf:type schema:DefinedTerm
86 N104e60c314f84e9db9cecebe9fe44820 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Lanthanum
88 rdf:type schema:DefinedTerm
89 N16ec20d548634fffa0bd9224930c3dd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Polyamines
91 rdf:type schema:DefinedTerm
92 N240e94e6d0154d4d91ba7e41fab01257 schema:name pubmed_id
93 schema:value 13483559
94 rdf:type schema:PropertyValue
95 N332271bf8944464aa965da2e18ae3bfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Diamines
97 rdf:type schema:DefinedTerm
98 N340e8ed9de4a4ce6a481cf4e757329be rdf:first sg:person.067646242.26
99 rdf:rest Na023a3d8bd11486fa0c71490167e54c0
100 N3a0d829359fd42b1a50c48cdca1b3fc6 rdf:first sg:person.053403431.23
101 rdf:rest N66ac92aa634e478c9d2eec4edd836479
102 N66ac92aa634e478c9d2eec4edd836479 rdf:first sg:person.0110331066.86
103 rdf:rest N08e3d1df66e84fca9da445b2cf87632f
104 N6a931d973311482793a1d8c0ce8fa422 schema:name doi
105 schema:value 10.1038/180919b0
106 rdf:type schema:PropertyValue
107 N8da0f5c8b5a24f8b922bf78faf51d4d6 schema:volumeNumber 180
108 rdf:type schema:PublicationVolume
109 N8e4dd14441584075b405432bc3af9a24 schema:name dimensions_id
110 schema:value pub.1016429111
111 rdf:type schema:PropertyValue
112 N94a2a1a6f1e14a2f9020cb9c955d5621 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Elements
114 rdf:type schema:DefinedTerm
115 N989dcf2c515c43ef82a521068e3f0fd9 schema:affiliation grid-institutes:grid.240283.f
116 schema:familyName KORMAN
117 schema:givenName SAMUEL
118 rdf:type schema:Person
119 Na023a3d8bd11486fa0c71490167e54c0 rdf:first sg:person.061542320.63
120 rdf:rest rdf:nil
121 Na696da39c9824042bac5c8016f12ac4b schema:affiliation grid-institutes:grid.240283.f
122 schema:familyName KROLL
123 schema:givenName HARRY
124 rdf:type schema:Person
125 Nad8b58c057434a59b312ff78105f3f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Yttrium
127 rdf:type schema:DefinedTerm
128 Nae4ef7deefed45a8a726fd40e11b160a schema:issueNumber 4592
129 rdf:type schema:PublicationIssue
130 Nd8b1107273ab4a83be316eac98a1ba07 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Ndec838abdfb343d8858a2929b7772da3 rdf:first N989dcf2c515c43ef82a521068e3f0fd9
133 rdf:rest N3a0d829359fd42b1a50c48cdca1b3fc6
134 Ndf50c0722cb541d0836eb3c9f1ef5b3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Pentetic Acid
136 rdf:type schema:DefinedTerm
137 Ne836c0cb64324652b17a48d1d0176084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chelating Agents
139 rdf:type schema:DefinedTerm
140 Nfe74d8b4b8de43dfa58a50c80a6de002 rdf:first Na696da39c9824042bac5c8016f12ac4b
141 rdf:rest Ndec838abdfb343d8858a2929b7772da3
142 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
143 schema:name Chemical Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:0302 schema:inDefinedTermSet anzsrc-for:
146 schema:name Inorganic Chemistry
147 rdf:type schema:DefinedTerm
148 sg:journal.1018957 schema:issn 0028-0836
149 1476-4687
150 schema:name Nature
151 schema:publisher Springer Nature
152 rdf:type schema:Periodical
153 sg:person.0110331066.86 schema:affiliation grid-institutes:grid.240283.f
154 schema:familyName HART
155 schema:givenName HIRAM E.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0110331066.86
157 rdf:type schema:Person
158 sg:person.053403431.23 schema:affiliation grid-institutes:grid.240283.f
159 schema:familyName SIEGEL
160 schema:givenName ELSIE
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053403431.23
162 rdf:type schema:Person
163 sg:person.061542320.63 schema:affiliation grid-institutes:grid.240283.f
164 schema:familyName LASZLO
165 schema:givenName DANIEL
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.061542320.63
167 rdf:type schema:Person
168 sg:person.063105631.72 schema:affiliation grid-institutes:grid.240283.f
169 schema:familyName ROSOFF
170 schema:givenName BETTY
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.063105631.72
172 rdf:type schema:Person
173 sg:person.067646242.26 schema:affiliation grid-institutes:grid.240283.f
174 schema:familyName SPENCER
175 schema:givenName HERTA
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067646242.26
177 rdf:type schema:Person
178 grid-institutes:grid.240283.f schema:alternateName Division of Neoplastic Diseases, Montefiore Hospital, 67, New York
179 schema:name Division of Neoplastic Diseases, Montefiore Hospital, 67, New York
180 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...