Female development in mammals is regulated by Wnt-4 signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-02

AUTHORS

Seppo Vainio, Minna Heikkilä, Andreas Kispert, Norman Chin, Andrew P. McMahon

ABSTRACT

In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development. Mullerian inhibiting substance and testosterone secreted by the differentiating embryonic testes result in the loss of female (Mullerian) or promotion of male (Wolffian) reproductive duct development, respectively. The signalling molecule Wnt-4 is crucial for female sexual development. At birth, sexual development in males with a mutation in Wnt-4 appears to be normal; however, Wnt-4-mutant females are masculinized-the Mullerian duct is absent while the Wolffian duct continues to develop. Wnt-4 is initially required in both sexes for formation of the Mullerian duct, then Wnt-4 in the developing ovary appears to suppress the development of Leydig cells; consequently, Wnt-4-mutant females ectopically activate testosterone biosynthesis. Wnt-4 may also be required for maintenance of the female germ line. Thus, the establishment of sexual dimorphism is under the control of both local and systemic signals. More... »

PAGES

405-409

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/17068

DOI

http://dx.doi.org/10.1038/17068

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036106583

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9989404


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