1950-10
AUTHORSJUNE LASCELLES, D. D. WOODS
ABSTRACTFOR some years there has been indirect evidence (reviewed, for example, by Woods1) that p-amino-benzoate has a function in the synthesis by micro-organisms of certain nucleic acid components and amino-acids. In the case of the former substances it is probable that the effect occurs through the intermediate formation of folic acid (pteroylglutamate) or related compounds which contain a p-aminobenzoate residue. One of the amino-acids implicated above is serine2, and this was chosen for the present studies since Sakami3, working with animal tissues, has shown its formation by condensation of glycine with a one-carbon compound such as formate. There is also evidence with several micro-organisms that glycine is a precursor of serine4,5. Holland and Meinke6 have found that under certain limited conditions Streptococcus fæcalisR requires serine for growth, and that such requirement may be largely abolished by increasing tenfold the concentration of pteroylglutamate. More... »
PAGES649-650
http://scigraph.springernature.com/pub.10.1038/166649a0
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