Synthesis of Serine by Micro-organisms View Full Text


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Article Info

DATE

1950-10

AUTHORS

JUNE LASCELLES, D. D. WOODS

ABSTRACT

FOR some years there has been indirect evidence (reviewed, for example, by Woods1) that p-amino-benzoate has a function in the synthesis by micro-organisms of certain nucleic acid components and amino-acids. In the case of the former substances it is probable that the effect occurs through the intermediate formation of folic acid (pteroylglutamate) or related compounds which contain a p-aminobenzoate residue. One of the amino-acids implicated above is serine2, and this was chosen for the present studies since Sakami3, working with animal tissues, has shown its formation by condensation of glycine with a one-carbon compound such as formate. There is also evidence with several micro-organisms that glycine is a precursor of serine4,5. Holland and Meinke6 have found that under certain limited conditions Streptococcus fæcalisR requires serine for growth, and that such requirement may be largely abolished by increasing tenfold the concentration of pteroylglutamate. More... »

PAGES

649-650

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/166649a0

DOI

http://dx.doi.org/10.1038/166649a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005817696

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14780185


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