p-Hydroxybenzoic Acid: a New Bacterial Vitamin View Full Text


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Article Info

DATE

1950-12

AUTHORS

BERNARD D. DAVIS

ABSTRACT

MUTANT 83-1 of Escherichia coli, isolated by the penicillin method1, is blocked at an early stage in aromatic synthesis; it responds to a quadruple supplement of tyrosine, phenylalanine, tryptophane and p-aminobenzoic acid. Whereas the quantitative requirements for the three amino-acids are similar to those of mutants with single requirements for these compounds, growth is very slow with 0.005 µgm./ml. of p-aminobenzoic acid, a concentration sufficient for optimal growth of a mutant blocked specifically in p-aminobenzoic acid synthesis. Higher concentrations of the acid, up to 1 µgm./ml., provide more rapid, yet less than normal, growth of mutant 83-1. Normal growth-rate, however, appears with the addition of shikimic acid (a 2,3,4,5-tetrahydrogallic acid). More... »

PAGES

1120-1121

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/1661120b0

DOI

http://dx.doi.org/10.1038/1661120b0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004885899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14796725


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